INT328626

Context Info Confidence 0.15 First Reported 2010 Last Reported 2010 Negated 0 Speculated 0 Reported most in Body Documents 1 Total Number 1 Disease Relevance 0.79 Pain Relevance 0

protein folding (TBCE) extracellular space (MUC16) extracellular region (MUC16) cell adhesion (MUC16) plasma membrane (MUC16) cytoskeleton (TBCE)

TBCE (Homo sapiens) MUC16 (Homo sapiens)

Pain Link Frequency Relevance Heat Inflammation 2 5.00 Inflammatory mediators 1 5.00 anesthesia 1 5.00 imagery 1 5.00

Disease Link Frequency Relevance Heat Syndrome 49 100.00 Sjoegrens Syndrome 31 100.00 Dry Eye 23 99.80 Cancer 1 79.68 Eye Disease 9 68.92 Disease 4 5.00 INFLAMMATION 3 5.00 Breast Cancer 2 5.00 Hypersensitivity 2 5.00 Disorders Of The Lacrimal System 2 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

If all transmembrane mucins are involved in resisting rose bengal penetration, then these data conflict in principle with our findings of increased levels of membrane bound MUC1 in SS versus NDE and no difference in membrane bound MUC16 in our previous work with SS, KCS and NDE [30], since rose bengal staining is found clinically in greater amounts in Sjogren’s syndrome patients [48].

KCS Binding (bound) of MUC16 associated with sjoegrens syndrome, syndrome and dry eye

1) Confidence 0.15 Published 2010 Journal Molecular Vision Section Body Doc Link PMC2927371 Disease Relevance 0.79 Pain Relevance 0

General Comments

This test has worked.