INT328692

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Context Info
Confidence 0.33
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 8
Disease Relevance 4.14
Pain Relevance 0.33

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
nerve 2
muscle 1
peripheral nerve 1
myotubes 1
Mir206 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Sciatic nerve 96 98.44 Very High Very High Very High
analgesia 8 5.00 Very Low Very Low Very Low
Demyelination 8 5.00 Very Low Very Low Very Low
anesthesia 8 5.00 Very Low Very Low Very Low
fibrosis 8 5.00 Very Low Very Low Very Low
Pain 8 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Nerve Compression Syndromes 240 99.68 Very High Very High Very High
Nervous System Injury 32 93.76 High High
Neurodegenerative Disease 8 88.88 High High
Motor Neuron Diseases 8 86.80 High High
Injury 128 86.32 High High
Disease 24 81.56 Quite High
Hypertrophy 8 76.88 Quite High
Muscle Disease 24 74.68 Quite High
Repression 8 62.08 Quite High
Muscular Atrophy 24 33.20 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
It was suggested that the increased expression of miR-206 in newly formed myotubes may reflect active regeneration and efficient maturation of skeletal muscle fibers [23].
Gene_expression (expression) of miR-206 in myotubes
1) Confidence 0.33 Published 2010 Journal BMC Musculoskelet Disord Section Body Doc Link PMC2927509 Disease Relevance 0.45 Pain Relevance 0.04
On the other hand, the expression of miR-206 was only significantly increased at 1 month after reinnervation, but not after denervation, and lasted for at least 4 months.
Gene_expression (expression) of miR-206
2) Confidence 0.33 Published 2010 Journal BMC Musculoskelet Disord Section Body Doc Link PMC2927509 Disease Relevance 0.51 Pain Relevance 0.04
Moreover, the expression of miR-206 may play a role in determining fiber type after peripheral nerve regeneration via the downregulation of the Mef2 transcript [22].
Gene_expression (expression) of miR-206 in peripheral nerve
3) Confidence 0.33 Published 2010 Journal BMC Musculoskelet Disord Section Body Doc Link PMC2927509 Disease Relevance 0.40 Pain Relevance 0.04
In contrast, we found no statistical difference in the expression of miR-206 during nerve entrapment or after decompression. miR-1 and miR-133a are transcribed from a common pre-miRNA precursor in the miR-1/miR-133a locus that generates different primary transcripts [33].
Gene_expression (expression) of miR-206 in nerve associated with nerve compression syndromes
4) Confidence 0.29 Published 2010 Journal BMC Musculoskelet Disord Section Body Doc Link PMC2927509 Disease Relevance 0.49 Pain Relevance 0.04
We previously demonstrated that the expression of miR-1 and miR-133 in the soleus muscle of rats increased by ~2-fold at 4 months after sciatic nerve denervation and after reinnervation with microanastomosis [22]; however, the expression of miR-206 was significantly increased by 3-fold at 1 month later and lasted for at least 4 months after reinnervation, but not after denervation [22].
Gene_expression (expression) of miR-206 in muscle associated with sciatic nerve
5) Confidence 0.29 Published 2010 Journal BMC Musculoskelet Disord Section Body Doc Link PMC2927509 Disease Relevance 0.33 Pain Relevance 0.05
In contrast, the expression pattern of miR-206 was found to be independent from those of miR-1 and miR-133a.
Gene_expression (expression) of miR-206
6) Confidence 0.28 Published 2010 Journal BMC Musculoskelet Disord Section Body Doc Link PMC2927509 Disease Relevance 0.66 Pain Relevance 0.03
In contrast, there were no statistical differences in the expression of miR-206 during nerve entrapment and after decompression.
Gene_expression (expression) of miR-206 in nerve associated with nerve compression syndromes
7) Confidence 0.22 Published 2010 Journal BMC Musculoskelet Disord Section Abstract Doc Link PMC2927509 Disease Relevance 0.57 Pain Relevance 0.08
In contrast, there were no statistical differences in the expression of miR-206 after entrapment and decompression.


Gene_expression (expression) of miR-206
8) Confidence 0.22 Published 2010 Journal BMC Musculoskelet Disord Section Body Doc Link PMC2927509 Disease Relevance 0.75 Pain Relevance 0

General Comments

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