INT328707

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Context Info
Confidence 0.02
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 2
Disease Relevance 2.32
Pain Relevance 0.24

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Trat1, Nos1) cytosol (Nos1) mitochondrion (Nos1)
oxidoreductase activity (Nos1) cytoskeleton (Nos1) nucleus (Nos1)
Anatomy Link Frequency
myocardium 1
Trat1 (Mus musculus)
Nos1 (Mus musculus)
Pain Link Frequency Relevance Heat
ischemia 54 95.00 High High
Central nervous system 2 5.00 Very Low Very Low Very Low
Neuronal nitric oxide synthase 2 5.00 Very Low Very Low Very Low
Peripheral nervous system 2 5.00 Very Low Very Low Very Low
Opioid 2 5.00 Very Low Very Low Very Low
Catecholamine 2 5.00 Very Low Very Low Very Low
Bioavailability 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Apoptosis 22 99.26 Very High Very High Very High
Necrosis 16 98.98 Very High Very High Very High
Injury 38 97.52 Very High Very High Very High
Cv Unclassified Under Development 50 95.00 High High
Targeted Disruption 24 89.68 High High
Death 6 72.76 Quite High
Myocardial Infarction 8 5.00 Very Low Very Low Very Low
Coronary Artery Disease 4 5.00 Very Low Very Low Very Low
Stress 4 5.00 Very Low Very Low Very Low
Diabetes Mellitus 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Figures 4a-c demonstrate that the reduction in CK release and in cell necrosis and apoptosis caused by the NO donor SNAP and the inhibition of nNOS with TRIM, was unaffected by the mitoKATP channel blocker 5-HD, and that, as expected, it blocked the protection by IP.
TRIM Negative_regulation (inhibition) of nNOS associated with necrosis and apoptosis
1) Confidence 0.02 Published 2010 Journal BMC Physiol Section Body Doc Link PMC2927582 Disease Relevance 1.35 Pain Relevance 0.15
Figures 1a-c show that, in the rat myocardium, the selective inhibition of nNOS by TRIM resulted in a significant reduction in CK release and in cell necrosis and apoptosis, as compared to the mean values in the ischemia/reoxygenation alone group.
TRIM Negative_regulation (inhibition) of nNOS in myocardium associated with necrosis, ischemia and apoptosis
2) Confidence 0.02 Published 2010 Journal BMC Physiol Section Body Doc Link PMC2927582 Disease Relevance 0.98 Pain Relevance 0.09

General Comments

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