INT328773

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Context Info
Confidence 0.41
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 5
Disease Relevance 4.00
Pain Relevance 0.17

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Ceacam1) plasma membrane (Ceacam1)
Ceacam1 (Mus musculus)
Pain Link Frequency Relevance Heat
Chronic pancreatitis 5 77.56 Quite High
metalloproteinase 20 56.28 Quite High
Inflammation 5 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Adhesions 35 99.76 Very High Very High Very High
Solid Tumor 5 99.64 Very High Very High Very High
Pancreatic Cancer 140 98.96 Very High Very High Very High
Cancer 315 98.40 Very High Very High Very High
Disease 20 96.44 Very High Very High Very High
Disease Progression 5 93.28 High High
Apoptosis 30 90.92 High High
Metastasis 90 85.56 High High
Malignant Neoplastic Disease 15 85.40 High High
Repression 5 81.88 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
To our knowledge, the simultaneous overexpression of CEACAM-1, -5 and -6 proteins in pancreatic cancer cells has not been reported before.
Positive_regulation (overexpression) of Gene_expression (overexpression) of CEACAM associated with pancreatic cancer
1) Confidence 0.41 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2927995 Disease Relevance 1.49 Pain Relevance 0.11
It was shown that CEACAM expression is elevated in many solid tumors [48,49].
Positive_regulation (elevated) of Gene_expression (expression) of CEACAM associated with solid tumor
2) Confidence 0.41 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2927995 Disease Relevance 1.43 Pain Relevance 0.06
Some pro-angiogenic factors (IL18, IL15, MMP10, MMP28) as well as cell adhesion molecules (CEACAM 1, CEACAM 5, CEACAM 6) were also overexpressed.
Positive_regulation (overexpressed) of Gene_expression (overexpressed) of CEACAM associated with adhesions
3) Confidence 0.35 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2927995 Disease Relevance 0.36 Pain Relevance 0
Some pro-angiogenic factors (IL18, IL15, MMP10, MMP28) as well as cell adhesion molecules (CEACAM 1, CEACAM 5, CEACAM 6) were also overexpressed.
Positive_regulation (overexpressed) of Gene_expression (overexpressed) of CEACAM associated with adhesions
4) Confidence 0.26 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2927995 Disease Relevance 0.36 Pain Relevance 0
Some pro-angiogenic factors (IL18, IL15, MMP10, MMP28) as well as cell adhesion molecules (CEACAM 1, CEACAM 5, CEACAM 6) were also overexpressed.
Positive_regulation (overexpressed) of Gene_expression (overexpressed) of CEACAM associated with adhesions
5) Confidence 0.26 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2927995 Disease Relevance 0.36 Pain Relevance 0

General Comments

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