INT3288

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.49
First Reported 1978
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 9
Total Number 9
Disease Relevance 5.55
Pain Relevance 1.10

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

biosynthetic process (Gpt) cellular_component (Gpt) biological_process (Gpt)
cytoplasm (Gpt)
Anatomy Link Frequency
liver 4
plasma 2
poly 2
Gpt (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Paracetamol 48 98.72 Very High Very High Very High
Angina 1 91.04 High High
pain flank 1 89.48 High High
Inflammation 35 81.12 Quite High
cva 7 80.04 Quite High
agonist 4 76.48 Quite High
fibrosis 24 75.00 Quite High
anesthesia 4 52.72 Quite High
Glutamate 12 5.00 Very Low Very Low Very Low
cytokine 10 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Hematuria 1 99.88 Very High Very High Very High
Proteinuria 1 99.66 Very High Very High Very High
Leukocytosis 1 99.40 Very High Very High Very High
Urological Neuroanatomy 6 99.28 Very High Very High Very High
Cancer 12 97.36 Very High Very High Very High
Injury 77 96.80 Very High Very High Very High
Poisoning 10 94.40 High High
Infection 4 93.52 High High
Fever 1 93.20 High High
Hepatotoxicity 37 93.16 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Serum alanine aminotransferase (ALT) and serum aspartate aminotransferase (AST) were estimated by International Federation of Clinical Chemistry.15 Serum bilirubin was estimated by Diazo method.16
Positive_regulation (estimated) of Gene_expression (estimated) of alanine aminotransferase
1) Confidence 0.49 Published 2008 Journal Indian Journal of Nephrology Section Body Doc Link PMC2813123 Disease Relevance 0.24 Pain Relevance 0.05
 ; (IL-6): interleukin-6; (ROS): reactive oxygen species; (PARP): poly (ADP-ribose) polymerase; (NO2/NO3): Nitrite/nitrate; (MPO): Myeloperoxidase activity; (ALT): alanine aminotransferase; (AST): aspartate aminotransferase; (iNOS): inducible nitric oxide.


Positive_regulation (inducible) of Gene_expression (oxide) of alanine aminotransferase in poly associated with urological neuroanatomy
2) Confidence 0.49 Published 2010 Journal J Inflamm (Lond) Section Body Doc Link PMC2844385 Disease Relevance 0.93 Pain Relevance 0.08
To improve the diagnostic value of the ALT assay and to understand the molecular basis for serum ALT changes in various pathophysiological conditions, we have cloned rat ALT isoenzyme ALT1 and ALT2 complementary DNAs (cDNAs), examined their tissue expressions at the messenger RNA and protein levels, and determined ALT1 and ALT 2 serum levels in response to liver damage in rodents.
Positive_regulation (rat) of Gene_expression (isoenzyme) of ALT1 in liver associated with hepatotoxicity
3) Confidence 0.47 Published 2009 Journal Hepatology Section Abstract Doc Link 19085960 Disease Relevance 0.84 Pain Relevance 0
To improve the diagnostic value of the ALT assay and to understand the molecular basis for serum ALT changes in various pathophysiological conditions, we have cloned rat ALT isoenzyme ALT1 and ALT2 complementary DNAs (cDNAs), examined their tissue expressions at the messenger RNA and protein levels, and determined ALT1 and ALT 2 serum levels in response to liver damage in rodents.
Positive_regulation (cloned) of Gene_expression (cloned) of ALT1 in liver associated with hepatotoxicity
4) Confidence 0.47 Published 2009 Journal Hepatology Section Abstract Doc Link 19085960 Disease Relevance 0.85 Pain Relevance 0
Animals fed corn oil and/or low protein levels showed significant increases in both GOT and GPT levels (Fig. 1).
Positive_regulation (increases) of Gene_expression (levels) of GPT
5) Confidence 0.45 Published 2009 Journal Nutrition Research and Practice Section Body Doc Link PMC2788177 Disease Relevance 0.57 Pain Relevance 0.39
Animals fed PUFA and/or low protein diet had significantly elevated plasma GPT and GOT levels and decreased GSH levels after acetaminophen challenge.
Positive_regulation (elevated) of Gene_expression (levels) of plasma GPT in plasma associated with paracetamol
6) Confidence 0.39 Published 2009 Journal Nutrition Research and Practice Section Body Doc Link PMC2788177 Disease Relevance 0.28 Pain Relevance 0.26
We generated F344 gpt delta rats because this background is frequently used for 2-year cancer bioassays.
Positive_regulation (generated) of Gene_expression (generated) of gpt associated with cancer
7) Confidence 0.39 Published 2010 Journal Toxicological Sciences Section Body Doc Link PMC2819973 Disease Relevance 0.30 Pain Relevance 0
Laboratory findings included leukocytosis, proteinuria, hematuria, and elevated levels of lactic dehydrogenase, serum glutamic-oxalacetic transaminase, serum glutamic-pyruvic transaminase, and alkaline phosphatase.
Positive_regulation (elevated) of Gene_expression (levels) of glutamic-pyruvic transaminase associated with proteinuria, leukocytosis and hematuria
8) Confidence 0.25 Published 1978 Journal Ann. Intern. Med. Section Abstract Doc Link 697226 Disease Relevance 1.31 Pain Relevance 0.29
Treatment with DMN significantly increased levels of serum alanine transaminase, aspartate transaminase, alkaline phosphatase, and bilirubin.
Positive_regulation (increased) of Gene_expression (levels) of serum alanine transaminase
9) Confidence 0.04 Published 2010 Journal Nutrition Research and Practice Section Abstract Doc Link PMC2981719 Disease Relevance 0.23 Pain Relevance 0.04

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox