INT328809

Context Info Confidence 0.35 First Reported 2010 Last Reported 2010 Negated 0 Speculated 0 Reported most in Body Documents 1 Total Number 2 Disease Relevance 0.32 Pain Relevance 0.65

nucleus (Jak1) cytoplasm (Jak1)

Jak1 (Rattus norvegicus)

Pain Link Frequency Relevance Heat cytokine 58 99.58 Potency 52 96.24 Arthritis 96 85.52 rheumatoid arthritis 44 84.40 Inflammation 42 50.00 psoriasis 6 5.00 anesthesia 2 5.00

Disease Link Frequency Relevance Heat Arthritis 104 85.52 Rheumatoid Arthritis 44 84.40 INFLAMMATION 40 50.00 Immunization 18 25.84 Disease 20 16.68 Hematological Disease 8 5.00 Psoriasis 6 5.00 Pressure And Volume Under Development 6 5.00 Reprotox - General 1 2 5.00 Hepatocellular Cancer 2 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Thus, while CP-690,550 can inhibit cytokine activation pathways associated with JAK1, subtle differences in JAK or STAT utilization by specific receptors may influence inhibitor potency and selectivity.

JAK1 Binding (associated) of associated with potency and cytokine

1) Confidence 0.35 Published 2010 Journal J Inflamm (Lond) Section Body Doc Link PMC2928212 Disease Relevance 0 Pain Relevance 0.37

While binding to the kinase domain of JAK1 was not examined in that study, it has been suggested that therapeutic efficacy of CP-690,550 in some indications may be due to cross-over inhibition of other JAKs [23].

JAK1 Binding (binding) of

2) Confidence 0.26 Published 2010 Journal J Inflamm (Lond) Section Body Doc Link PMC2928212 Disease Relevance 0.32 Pain Relevance 0.28

General Comments

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