INT328809

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Context Info
Confidence 0.35
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 2
Disease Relevance 0.32
Pain Relevance 0.65

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (Jak1) cytoplasm (Jak1)
Jak1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
cytokine 58 99.58 Very High Very High Very High
Potency 52 96.24 Very High Very High Very High
Arthritis 96 85.52 High High
rheumatoid arthritis 44 84.40 Quite High
Inflammation 42 50.00 Quite Low
psoriasis 6 5.00 Very Low Very Low Very Low
anesthesia 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Arthritis 104 85.52 High High
Rheumatoid Arthritis 44 84.40 Quite High
INFLAMMATION 40 50.00 Quite Low
Immunization 18 25.84 Quite Low
Disease 20 16.68 Low Low
Hematological Disease 8 5.00 Very Low Very Low Very Low
Psoriasis 6 5.00 Very Low Very Low Very Low
Pressure And Volume Under Development 6 5.00 Very Low Very Low Very Low
Reprotox - General 1 2 5.00 Very Low Very Low Very Low
Hepatocellular Cancer 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Thus, while CP-690,550 can inhibit cytokine activation pathways associated with JAK1, subtle differences in JAK or STAT utilization by specific receptors may influence inhibitor potency and selectivity.
JAK1 Binding (associated) of associated with potency and cytokine
1) Confidence 0.35 Published 2010 Journal J Inflamm (Lond) Section Body Doc Link PMC2928212 Disease Relevance 0 Pain Relevance 0.37
While binding to the kinase domain of JAK1 was not examined in that study, it has been suggested that therapeutic efficacy of CP-690,550 in some indications may be due to cross-over inhibition of other JAKs [23].
JAK1 Binding (binding) of
2) Confidence 0.26 Published 2010 Journal J Inflamm (Lond) Section Body Doc Link PMC2928212 Disease Relevance 0.32 Pain Relevance 0.28

General Comments

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