INT328815

Context Info Confidence 0.32 First Reported 2010 Last Reported 2010 Negated 0 Speculated 0 Reported most in Body Documents 1 Total Number 1 Disease Relevance 0.88 Pain Relevance 0.24

nucleus (Jak1) cytoplasm (Jak1)

Anatomy Link Frequency blood 2 Jak1 (Rattus norvegicus)

Pain Link Frequency Relevance Heat Arthritis 48 84.56 Inflammation 21 68.36 cytokine 29 38.12 Potency 26 5.00 rheumatoid arthritis 22 5.00 psoriasis 3 5.00 anesthesia 1 5.00

Disease Link Frequency Relevance Heat Immunization 9 89.44 Arthritis 52 84.56 Disease 10 74.36 INFLAMMATION 20 68.36 Disease Progression 1 43.84 Rheumatoid Arthritis 22 5.00 Hematological Disease 4 5.00 Psoriasis 3 5.00 Pressure And Volume Under Development 3 5.00 Reprotox - General 1 1 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

These data suggest the importance of JAK1 and JAK3 inhibition for efficacy, since ED50 exposures were below those needed for JAK2 inhibition in whole blood.

Regulation (importance) of Negative_regulation (inhibition) of JAK1 in blood

1) Confidence 0.32 Published 2010 Journal J Inflamm (Lond) Section Body Doc Link PMC2928212 Disease Relevance 0.88 Pain Relevance 0.24

General Comments

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