INT328816

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Context Info
Confidence 0.30
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 0.88
Pain Relevance 0.24

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytoskeleton (Jak3) transcription factor binding (Jak3) cytoplasm (Jak3)
Anatomy Link Frequency
blood 2
Jak3 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Arthritis 48 84.56 Quite High
Inflammation 21 68.36 Quite High
cytokine 29 38.12 Quite Low
Potency 26 5.00 Very Low Very Low Very Low
rheumatoid arthritis 22 5.00 Very Low Very Low Very Low
psoriasis 3 5.00 Very Low Very Low Very Low
anesthesia 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Immunization 9 89.44 High High
Arthritis 52 84.56 Quite High
Disease 10 74.36 Quite High
INFLAMMATION 20 68.36 Quite High
Disease Progression 1 43.84 Quite Low
Rheumatoid Arthritis 22 5.00 Very Low Very Low Very Low
Hematological Disease 4 5.00 Very Low Very Low Very Low
Psoriasis 3 5.00 Very Low Very Low Very Low
Pressure And Volume Under Development 3 5.00 Very Low Very Low Very Low
Reprotox - General 1 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
These data suggest the importance of JAK1 and JAK3 inhibition for efficacy, since ED50 exposures were below those needed for JAK2 inhibition in whole blood.
Regulation (importance) of Negative_regulation (inhibition) of JAK3 in blood
1) Confidence 0.30 Published 2010 Journal J Inflamm (Lond) Section Body Doc Link PMC2928212 Disease Relevance 0.88 Pain Relevance 0.24

General Comments

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