INT328828

Context Info Confidence 0.24 First Reported 2010 Last Reported 2010 Negated 0 Speculated 0 Reported most in Body Documents 1 Total Number 1 Disease Relevance 0 Pain Relevance 0.38

nucleus (Jak2, Jak1) cytoplasm (Jak2, Jak1) cell differentiation (Jak2) cytosol (Jak2) signal transduction (Jak2) histone binding (Jak2)

Jak2 (Rattus norvegicus) Jak1 (Rattus norvegicus)

Pain Link Frequency Relevance Heat cytokine 29 95.60 Potency 26 92.08 Inflammation 21 50.00 Arthritis 48 41.56 rheumatoid arthritis 22 40.44 psoriasis 3 5.00 anesthesia 1 5.00

Disease Link Frequency Relevance Heat INFLAMMATION 20 50.00 Arthritis 52 41.56 Rheumatoid Arthritis 22 40.44 Disease 10 5.00 Immunization 9 5.00 Hematological Disease 4 5.00 Psoriasis 3 5.00 Pressure And Volume Under Development 3 5.00 Reprotox - General 1 1 5.00 Hepatocellular Cancer 1 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Although the gp130 component of the IL-6 receptor complex can associate with JAK1, JAK2 or TYK2, JAK1 plays an essential role in cell signaling, since JAK1-deficient cells fail to respond to IL-6 or other gp130 cytokines [24].

JAK2 Binding (associate) of JAK1 associated with cytokine

1) Confidence 0.24 Published 2010 Journal J Inflamm (Lond) Section Body Doc Link PMC2928212 Disease Relevance 0 Pain Relevance 0.38

General Comments

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