INT32889

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Context Info
Confidence 0.49
First Reported 1985
Last Reported 2010
Negated 1
Speculated 1
Reported most in Abstract
Documents 6
Total Number 7
Disease Relevance 1.69
Pain Relevance 4.60

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Pde4dl1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
IPN 56 99.84 Very High Very High Very High
antinociception 2 99.54 Very High Very High Very High
Antinociceptive 4 99.52 Very High Very High Very High
lidocaine 3 98.64 Very High Very High Very High
adenocard 4 93.92 High High
Hyperalgesia 2 88.56 High High
Spinal cord 2 60.20 Quite High
sSRI 11 54.92 Quite High
intrathecal 1 53.96 Quite High
antagonist 4 34.48 Quite Low
Disease Link Frequency Relevance Heat
Pressure And Volume Under Development 4 96.60 Very High Very High Very High
Hepatocellular Cancer 4 96.28 Very High Very High Very High
Appetite Loss 19 93.68 High High
Aging 3 90.56 High High
Nociception 4 85.16 High High
Hyperalgesia 2 64.40 Quite High
Gastric Motility Disorder 2 38.20 Quite Low
Adverse Drug Reaction 4 10.00 Low Low
Vomiting 7 5.00 Very Low Very Low Very Low
Dyspepsia 4 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Moreover, rikkunshito is also an enhancement of ghrelin receptor reactivity via PDE3 inhibition.
Positive_regulation (enhancement) of PDE3
1) Confidence 0.49 Published 2010 Journal International Journal of Peptides Section Body Doc Link PMC2915625 Disease Relevance 0.77 Pain Relevance 0.03
The addition of mitomycin C (MMC) at 15 min after the initiation of the treatment with IPN inhibited the increase in the activity of cyclic AMP phosphodiesterase in a dose-dependent manner.
Positive_regulation (increase) of cyclic AMP phosphodiesterase associated with ipn
2) Confidence 0.48 Published 1986 Journal J. Pharmacobio-dyn. Section Abstract Doc Link 3025407 Disease Relevance 0.15 Pain Relevance 1.00
The activity of cyclic AMP phosphodiesterase was increased by IPN in a dose-dependent manner and reached a maximal increase at 30 min after the addition of 10(-4)M IPN.
Positive_regulation (increased) of cyclic AMP phosphodiesterase associated with ipn
3) Confidence 0.48 Published 1986 Journal J. Pharmacobio-dyn. Section Abstract Doc Link 3025407 Disease Relevance 0.15 Pain Relevance 0.71
These results show that the treatment of AH130 cells with IPN caused an induction of cyclic AMP phosphodiesterase and the development of desensitization of adenylate cyclase.
Positive_regulation (induction) of cyclic AMP phosphodiesterase associated with ipn
4) Confidence 0.48 Published 1986 Journal J. Pharmacobio-dyn. Section Abstract Doc Link 3025407 Disease Relevance 0.15 Pain Relevance 1.12
The action of mitomycin C on the induction of cyclic AMP phosphodiesterase and the development of desensitization of adenylate cyclase by isoproterenol in rat ascites hepatoma AH130 cells.
Positive_regulation (induction) of cyclic AMP phosphodiesterase associated with pressure and volume under development and hepatocellular cancer
5) Confidence 0.48 Published 1986 Journal J. Pharmacobio-dyn. Section Title Doc Link 3025407 Disease Relevance 0.19 Pain Relevance 0.87
On the other hand, 8-bromo-cGMP evoked antinociception appears to be largely independent of PKG-I, CNGs, PDE2 and PDE3.
Neg (independent) Spec (appears) Positive_regulation (independent) of PDE3 associated with antinociception
6) Confidence 0.44 Published 2002 Journal Neurosci. Lett. Section Abstract Doc Link 12384231 Disease Relevance 0.28 Pain Relevance 0.60
The incubation of rat myocardial sarcolemmal membranes with 10(-4)M lidocaine or procainamide results in a decreased fluorescence polarization of the extrinsic probes (diphenylhexatriene and 12-anthroylstearate) and in the stimulation of the membrane-bound high affinity cyclic AMP phosphodiesterase activity (PDE).
Positive_regulation (stimulation) of cyclic AMP phosphodiesterase associated with lidocaine
7) Confidence 0.33 Published 1985 Journal Gen. Pharmacol. Section Abstract Doc Link 2987079 Disease Relevance 0 Pain Relevance 0.27

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