INT32890

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Context Info
Confidence 0.44
First Reported 1985
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 3
Total Number 3
Disease Relevance 0.88
Pain Relevance 0.41

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
myocardium 1
Pde4dl1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
lidocaine 4 100.00 Very High Very High Very High
sSRI 11 71.40 Quite High
antagonist 4 50.96 Quite High
agonist 1 42.04 Quite Low
Central nervous system 1 40.64 Quite Low
nud 4 5.00 Very Low Very Low Very Low
Chronic pancreatitis 1 5.00 Very Low Very Low Very Low
5HT 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Appetite Loss 19 95.36 Very High Very High Very High
Aging 3 87.52 High High
Gastric Motility Disorder 2 54.68 Quite High
Adverse Drug Reaction 4 26.48 Quite Low
Vomiting 7 5.00 Very Low Very Low Very Low
Dyspepsia 4 5.00 Very Low Very Low Very Low
Gastrointestinal Disease 3 5.00 Very Low Very Low Very Low
Gastritis 2 5.00 Very Low Very Low Very Low
Ulcers 1 5.00 Very Low Very Low Very Low
Advanced Or Metastatic Breast Cancer 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The components of rikkunshito (nobiletin, isoliquiritigenin, and heptamethoxyflavone) had inhibitory effects on PDE3 activity.
Regulation (effects) of PDE3
1) Confidence 0.44 Published 2010 Journal International Journal of Peptides Section Body Doc Link PMC2915625 Disease Relevance 0.88 Pain Relevance 0.06
The effects of lidocaine and procainamide on the sarcolemmal membrane high affinity cyclic AMP phosphodiesterase of rat myocardium.
Regulation (effects) of cyclic AMP phosphodiesterase in myocardium associated with lidocaine
2) Confidence 0.17 Published 1985 Journal Gen. Pharmacol. Section Title Doc Link 2987079 Disease Relevance 0 Pain Relevance 0.28
Mycelia of Phymatotrichum omnivorum obtained at 10 day intervals during 10 to 50 days of growth were used for isolating calmodulin, and studying its effect on glycogen synthase, phosphorylase, phosphorylase kinase, cyclic AMP phosphodiesterase and Ca++ATPase.
Regulation (effect) of cyclic AMP phosphodiesterase
3) Confidence 0.01 Published 1993 Journal Microbios Section Abstract Doc Link 8382768 Disease Relevance 0 Pain Relevance 0.06

General Comments

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