INT329004

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Context Info
Confidence 0.00
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 0.70
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

structural molecule activity (MPZ) plasma membrane (MPZ) ligase activity (RNF123)
cytoplasm (RNF123)
MPZ (Homo sapiens)
RNF123 (Homo sapiens)
Pain Link Frequency Relevance Heat
Action potential 3 5.00 Very Low Very Low Very Low
Peripheral nervous system 2 5.00 Very Low Very Low Very Low
peripheral neuropathy 1 5.00 Very Low Very Low Very Low
Demyelination 1 5.00 Very Low Very Low Very Low
Pain 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Mouth Disease 32 100.00 Very High Very High Very High
Neurodegenerative Disease 2 98.72 Very High Very High Very High
Targeted Disruption 1 97.00 Very High Very High Very High
Acquired Immune Deficiency Syndrome Or Hiv Infection 1 87.76 High High
Cancer 1 84.40 Quite High
Charcot Marie Tooth Disease 14 59.76 Quite High
Epstein-barr Virus 2 48.56 Quite Low
Peripheral Neuropathy 3 5.00 Very Low Very Low Very Low
Disease 3 5.00 Very Low Very Low Very Low
Neuropathic Pain 3 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Moreover, the known CMT gene LITAF, also called SIMPLE, interacts with mouse ubiquitin ligase gene product NEDD4 [23], also potentially with TSG101 [24], and may itself be an E3 ubiquitin ligase [25], These related findings support the interpretation that mutation of LRSAM1 is probably causal in our patients.
CMT Binding (interacts) of ubiquitin ligase associated with mouth disease
1) Confidence 0.00 Published 2010 Journal PLoS Genetics Section Body Doc Link PMC2928813 Disease Relevance 0.70 Pain Relevance 0

General Comments

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