INT329021

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Context Info
Confidence 0.09
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 2.04
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (Notch3) plasma membrane (Notch3) nucleus (Notch3)
Anatomy Link Frequency
smooth muscle cells 2
Notch3 (Mus musculus)
Pain Link Frequency Relevance Heat
cva 6 5.00 Very Low Very Low Very Low
Inflammation 4 5.00 Very Low Very Low Very Low
Inflammatory response 2 5.00 Very Low Very Low Very Low
antagonist 2 5.00 Very Low Very Low Very Low
aspirin 1 5.00 Very Low Very Low Very Low
cytokine 1 5.00 Very Low Very Low Very Low
cINOD 1 5.00 Very Low Very Low Very Low
ischemia 1 5.00 Very Low Very Low Very Low
Inflammatory mediators 1 5.00 Very Low Very Low Very Low
beta blocker 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Cadasil 6 98.98 Very High Very High Very High
Targeted Disruption 7 98.62 Very High Very High Very High
Vascular Disease 1 89.76 High High
Alzheimer's Dementia 1 89.32 High High
Atherosclerosis 31 88.80 High High
Leukoencephalopathies 2 87.76 High High
Cv General 4 Under Development 3 86.92 High High
Cognitive Disorder 1 75.72 Quite High
Brain Hemorrhage 1 74.36 Quite High
Stroke 49 73.12 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Recently a transgenic mouse model for CADASIL has been developed in which the full-length human Notch3 carrying the Arg90Cys mutation is expressed under the SM22 promoter in vascular smooth muscle cells [90].
Regulation (under) of Gene_expression (expressed) of Notch3 in smooth muscle cells associated with targeted disruption and cadasil
1) Confidence 0.09 Published 2010 Journal The Open Neurology Journal Section Body Doc Link PMC2928914 Disease Relevance 2.04 Pain Relevance 0

General Comments

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