INT329023

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Context Info
Confidence 0.18
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 1.36
Pain Relevance 0.07

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Cbs) lyase activity (Cbs) nucleolus (Cbs)
nucleus (Cbs) enzyme binding (Cbs) cytoplasm (Cbs)
Anatomy Link Frequency
plasma 1
Cbs (Mus musculus)
Pain Link Frequency Relevance Heat
cva 6 74.88 Quite High
beta blocker 1 20.92 Low Low
antagonist 2 19.60 Low Low
Inflammation 4 5.00 Very Low Very Low Very Low
Inflammatory response 2 5.00 Very Low Very Low Very Low
aspirin 1 5.00 Very Low Very Low Very Low
cytokine 1 5.00 Very Low Very Low Very Low
cINOD 1 5.00 Very Low Very Low Very Low
ischemia 1 5.00 Very Low Very Low Very Low
Inflammatory mediators 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Hyperhomocysteinemia 15 99.54 Very High Very High Very High
Targeted Disruption 7 98.04 Very High Very High Very High
Dislocations 1 84.16 Quite High
Apoptosis 1 83.12 Quite High
Thrombosis Related Under Development 3 74.88 Quite High
Cardiovascular Disease 7 73.76 Quite High
Stroke 49 72.80 Quite High
Homocystinuria 1 71.28 Quite High
Myocardial Infarction 4 65.04 Quite High
Atherosclerotic Plaque 5 44.80 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The first genetic model of hyperhomocysteinemia in mice was developed in 1995 through targeted disruption of the CBS gene thereby establishing a severe form of hyperhomocysteinemia induced by homozygous CBS-deficiency (plasma levels of homocysteine elevated by 40-fold with plasma concentrations above 200 ┬Ámol L-1) and a mild form in heterozygous CBS deficiency (plasma concentration 6-15 ┬Ámol L-1) [73].
Positive_regulation (elevated) of CBS in plasma associated with targeted disruption and hyperhomocysteinemia
1) Confidence 0.18 Published 2010 Journal The Open Neurology Journal Section Body Doc Link PMC2928914 Disease Relevance 1.36 Pain Relevance 0.07

General Comments

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