INT329028

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Context Info
Confidence 0.79
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 2
Disease Relevance 0.32
Pain Relevance 0.60

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Tub) extracellular region (Tub) plasma membrane (Tub)
nucleus (Tub) molecular_function (Tub) cellular_component (Tub)
Anatomy Link Frequency
neuronal 2
Tub (Rattus norvegicus)
Pain Link Frequency Relevance Heat
fluoxetine 40 99.70 Very High Very High Very High
Hippocampus 4 80.72 Quite High
depression 30 76.12 Quite High
Serotonin 34 60.88 Quite High
5HT 2 43.04 Quite Low
antidepressant 26 5.00 Very Low Very Low Very Low
sSRI 20 5.00 Very Low Very Low Very Low
monoamine 10 5.00 Very Low Very Low Very Low
noradrenaline 8 5.00 Very Low Very Low Very Low
Neurotransmitter 6 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Stress 8 98.80 Very High Very High Very High
Depression 36 76.12 Quite High
Neurodegenerative Disease 4 5.00 Very Low Very Low Very Low
Depressive Disorder 2 5.00 Very Low Very Low Very Low
Aggression 2 5.00 Very Low Very Low Very Low
Congenital Anomalies 2 5.00 Very Low Very Low Very Low
Death 2 5.00 Very Low Very Low Very Low
Anxiety Disorder 2 5.00 Very Low Very Low Very Low
Frailty 2 5.00 Very Low Very Low Very Low
Affective Disorder 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
On the other hand, fluoxetine was reported to have the ability to reverse stress-induced changes [56, 57] and that fluoxetine increases the phosphorylation of MAP-2 [58] that is amongst neuronal microtubule-associated proteins (MAPs) an abundant group of cytoskeletal components.
Phosphorylation (phosphorylation) of tub in neuronal associated with stress and fluoxetine
1) Confidence 0.79 Published 2010 Journal The Open Neurology Journal Section Body Doc Link PMC2928987 Disease Relevance 0.16 Pain Relevance 0.38
It has been shown that different acute stressful conditions [i.e. 5-min forced swim in cold water] result in hyperphosphorylation of microtubule-associated proteins such as TAU [54] and that neuronal TAU hyperphosphorylation decreases microtubule dynamics resulting in neuronal plasticity impairment [55].
Phosphorylation (hyperphosphorylation) of tub in neuronal
2) Confidence 0.61 Published 2010 Journal The Open Neurology Journal Section Body Doc Link PMC2928987 Disease Relevance 0.16 Pain Relevance 0.23

General Comments

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