INT329029

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Context Info
Confidence 0.44
First Reported 2010
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 1
Total Number 2
Disease Relevance 0.07
Pain Relevance 0.30

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Tub) extracellular region (Tub) plasma membrane (Tub)
nucleus (Tub) molecular_function (Tub) cellular_component (Tub)
Anatomy Link Frequency
band 2
Tub (Rattus norvegicus)
Pain Link Frequency Relevance Heat
5HT 2 99.68 Very High Very High Very High
antidepressant 26 71.72 Quite High
fluoxetine 40 68.96 Quite High
sSRI 20 64.00 Quite High
depression 30 42.00 Quite Low
Serotonin 34 35.04 Quite Low
monoamine 10 31.64 Quite Low
noradrenaline 8 5.00 Very Low Very Low Very Low
Neurotransmitter 6 5.00 Very Low Very Low Very Low
Hippocampus 4 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Depression 36 69.52 Quite High
Carcinoma 2 19.72 Low Low
Stress 8 18.68 Low Low
Neurodegenerative Disease 4 5.00 Very Low Very Low Very Low
Depressive Disorder 2 5.00 Very Low Very Low Very Low
Aggression 2 5.00 Very Low Very Low Very Low
Congenital Anomalies 2 5.00 Very Low Very Low Very Low
Death 2 5.00 Very Low Very Low Very Low
Anxiety Disorder 2 5.00 Very Low Very Low Very Low
Frailty 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Tyr-Tub expression was evaluated in brain homogenate by densitometric quantification of related band previously obtained via western blot.
Regulation (evaluated) of Gene_expression (expression) of Tub in band
1) Confidence 0.44 Published 2010 Journal The Open Neurology Journal Section Body Doc Link PMC2928987 Disease Relevance 0.07 Pain Relevance 0.19
Therefore, this data indicate that the reduction of 5HT levels and Tyr-tub expression following FST is not altered significantly by the manipulation of the animal when submitted to i.p. treatment, thus supporting both these reductions as directly related to the FST and independent from the putative stressful manipulation of the animal due to the systemic injection.
Neg (not) Regulation (altered) of Gene_expression (expression) of tub associated with 5ht
2) Confidence 0.44 Published 2010 Journal The Open Neurology Journal Section Body Doc Link PMC2928987 Disease Relevance 0 Pain Relevance 0.12

General Comments

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