INT32903

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Context Info
Confidence 0.48
First Reported 1983
Last Reported 2008
Negated 0
Speculated 0
Reported most in Abstract
Documents 14
Total Number 14
Disease Relevance 5.02
Pain Relevance 7.20

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

small molecule metabolic process (PPAP2A) plasma membrane (PPAP2A) lipid metabolic process (PPAP2A)
Anatomy Link Frequency
platelet 3
blood 2
muscle 1
posterior 1
neural 1
PPAP2A (Homo sapiens)
Pain Link Frequency Relevance Heat
Clonidine 48 100.00 Very High Very High Very High
agonist 27 100.00 Very High Very High Very High
Pain 36 99.56 Very High Very High Very High
antidepressant 4 99.32 Very High Very High Very High
depression 8 99.06 Very High Very High Very High
tricyclic antidepressant 4 98.84 Very High Very High Very High
Dopamine 80 94.68 High High
nMDA receptor 3 90.12 High High
Pyramidal cell 12 84.80 Quite High
antagonist 5 83.44 Quite High
Disease Link Frequency Relevance Heat
Heart Rate Under Development 10 99.78 Very High Very High Very High
Myalgia 6 99.68 Very High Very High Very High
Coronary Artery Disease 4 99.52 Very High Very High Very High
Obesity 23 99.06 Very High Very High Very High
Depression 12 99.06 Very High Very High Very High
Lumbar Puncture Related Headaches 2 91.00 High High
Pain 9 88.40 High High
Disease 1 80.72 Quite High
Cognitive Disorder 17 75.52 Quite High
Attention Deficit Hyperactivity Disorder 36 70.32 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
This increase was observed to be sensitive to the PAP-1 inhibitors.
Negative_regulation (inhibitors) of PAP-1
1) Confidence 0.48 Published 2006 Journal J. Biol. Chem. Section Abstract Doc Link 16950767 Disease Relevance 0.06 Pain Relevance 0.06
Thus, the differences in the lipolytic responses to epinephrine in adipocytes from different sites are linked to a variable alpha-2 inhibiting effect (and alpha-2 site number) rather than to a modified beta driven increase in lipolysis initiated by the physiological amine.
Negative_regulation (inhibiting) of alpha-2 in adipocytes associated with obesity
2) Confidence 0.41 Published 1987 Journal Eur. J. Clin. Invest. Section Abstract Doc Link 3034620 Disease Relevance 0.64 Pain Relevance 0.20
However, the number of alpha-2 adrenoceptor sites, identified by [3H]clonidine was reduced (40-50%).
Negative_regulation (reduced) of alpha-2 associated with clonidine
3) Confidence 0.37 Published 1985 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 2987483 Disease Relevance 0.92 Pain Relevance 1.12
This study supports the hypothesis that increased levels of circulating norepinephrine in CHF lead to a decrease in platelet alpha 2 adrenoreceptors.
Negative_regulation (decrease) of alpha 2 in platelet associated with heart rate under development
4) Confidence 0.37 Published 1983 Journal Am. J. Cardiol. Section Abstract Doc Link 6305182 Disease Relevance 0.23 Pain Relevance 0.26
Alpha-2 adrenergic agonists including clonidine decrease cerebral blood flow.
Negative_regulation (decrease) of Alpha-2 in blood associated with agonist and clonidine
5) Confidence 0.37 Published 2000 Journal J Nippon Med Sch Section Abstract Doc Link 11116238 Disease Relevance 0.08 Pain Relevance 0.62
The decreases in theta and alpha-1 (8-10.5 Hz) activity in central and posterior parietal parts were evoked by non-painful stimulation, but the decreases in alpha-1 and alpha-2 (11-13.5 Hz) activities in the posterior part of the head were induced by painful stimulation.
Negative_regulation (decreases) of alpha-2 in posterior associated with pain
6) Confidence 0.25 Published 2001 Journal Exp Brain Res Section Abstract Doc Link 11713631 Disease Relevance 0.50 Pain Relevance 1.68
Treatment of endogenously depressed patients with tricyclic antidepressants, lithium salts or electroconvulsive therapy results in a decrease in the number of alpha 2 adrenoreceptors on blood platelet membranes.
Negative_regulation (decrease) of alpha 2 in blood platelet associated with tricyclic antidepressant
7) Confidence 0.16 Published 1983 Journal Prog. Neuropsychopharmacol. Biol. Psychiatry Section Abstract Doc Link 6310693 Disease Relevance 0.43 Pain Relevance 0.33
These studies suggest that a supersensitivity of the alpha 2 adrenoreceptor might exist in patients with endogenous depression and that effective forms of therapy lead to a decrease in the number of neural alpha 2 adrenoreceptors which is reflected by a decrease in the number of these receptors upon blood platelet membranes.
Negative_regulation (decrease) of alpha 2 in neural associated with depression
8) Confidence 0.14 Published 1983 Journal Prog. Neuropsychopharmacol. Biol. Psychiatry Section Abstract Doc Link 6310693 Disease Relevance 0.40 Pain Relevance 0.30
In patients with severe congestive heart failure or with symptomatic coronary artery disease the number of platelet alpha 2 adrenoreceptors is actually decreased.
Negative_regulation (decreased) of alpha 2 in heart associated with heart rate under development and coronary artery disease
9) Confidence 0.14 Published 1983 Journal Prog. Neuropsychopharmacol. Biol. Psychiatry Section Abstract Doc Link 6310693 Disease Relevance 0.44 Pain Relevance 0.34
Platelet alpha 2 adrenoreceptors are decreased in number after antidepressant therapy.
Negative_regulation (decreased) of alpha 2 in Platelet associated with antidepressant
10) Confidence 0.14 Published 1983 Journal Prog. Neuropsychopharmacol. Biol. Psychiatry Section Title Doc Link 6310693 Disease Relevance 0.41 Pain Relevance 0.34
Forskolin or 8-bromo-cAMP, which alone enhanced norepinephrine secretion, failed to attenuate the inhibitory responses to alpha-2 agonists. 3H-rauwolscine binding measurements showed a small decrease in alpha-2 receptor sites in iris-ciliary body membranes following surgical sympathetic denervation.
Negative_regulation (decrease) of alpha-2 in sympathetic associated with agonist
11) Confidence 0.10 Published 1987 Journal Curr. Eye Res. Section Abstract Doc Link 3038473 Disease Relevance 0 Pain Relevance 0.36
Our data confirm previous reports of alpha 2-noradrenergic inhibition of neurohypophyseal release of AVP into blood, and extend these findings to healthy human subjects.
Negative_regulation (inhibition) of alpha 2-noradrenergic in blood
12) Confidence 0.06 Published 1987 Journal Neuroendocrinology Section Abstract Doc Link 3431654 Disease Relevance 0.17 Pain Relevance 0.41
The alpha-1 EEG powers at P3, Pz, P4, PC1, PC2 and POz, and alpha-2 at Pz and POz sites were significantly decreased during muscle pain when compared with aversive noise stimulation.
Negative_regulation (decreased) of alpha-2 in muscle associated with pain and myalgia
13) Confidence 0.05 Published 2002 Journal Exp Brain Res Section Abstract Doc Link 12428146 Disease Relevance 0.60 Pain Relevance 0.80
Arnsten and Dudley [66] have shown that the PFC-enhancing effects of methylphenidate are prevented by blockade of either NE alpha-2 or DAD1 receptors, suggesting that stimulants facilitate endogenous stimulation of D1 and alpha-2A receptors in the PFC.
Negative_regulation (blockade) of alpha-2 in PFC
14) Confidence 0.01 Published 2008 Journal Behav Brain Funct Section Body Doc Link PMC2289834 Disease Relevance 0.15 Pain Relevance 0.36

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