INT32905

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Context Info
Confidence 0.58
First Reported 1982
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 18
Total Number 19
Disease Relevance 11.07
Pain Relevance 3.54

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endosome (Mrc1) signal transduction (Mrc1) plasma membrane (Mrc1)
Anatomy Link Frequency
macrophages 2
amygdala 2
vasculature 1
colon 1
germline 1
Mrc1 (Mus musculus)
Pain Link Frequency Relevance Heat
agonist 17 99.96 Very High Very High Very High
analgesia 2 99.96 Very High Very High Very High
Hippocampus 63 99.94 Very High Very High Very High
amygdala 18 99.68 Very High Very High Very High
Hyperalgesia 6 99.40 Very High Very High Very High
antidepressant 39 98.84 Very High Very High Very High
Spinal cord 5 96.40 Very High Very High Very High
Inflammation 33 94.88 High High
dexamethasone 10 94.48 High High
Opioid 5 94.40 High High
Disease Link Frequency Relevance Heat
Cancer 826 100.00 Very High Very High Very High
Apoptosis 311 99.70 Very High Very High Very High
Sprains And Strains 17 99.60 Very High Very High Very High
Hyperalgesia 6 99.40 Very High Very High Very High
Endometrial Cancer 98 97.98 Very High Very High Very High
Stress 140 97.64 Very High Very High Very High
Frailty 2 96.40 Very High Very High Very High
INFLAMMATION 45 94.88 High High
Depression 74 94.20 High High
Nociception 4 93.92 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
However, the effect of Mr-2267 on OTMN was biphasic and this contrasted with Mr-1453 which produced consistent and graded antagonism.
Gene_expression (produced) of Mr-1453
1) Confidence 0.58 Published 1982 Journal J. Pharm. Pharmacol. Section Abstract Doc Link 6126560 Disease Relevance 0 Pain Relevance 0.84
Mr2096 and Mr2097 respectively produced analgesia and hyperalgesia in these strains of mice.
Gene_expression (produced) of Mr2096 associated with hyperalgesia, sprains and strains and analgesia
2) Confidence 0.51 Published 1985 Journal Jpn. J. Pharmacol. Section Abstract Doc Link 2987591 Disease Relevance 0.71 Pain Relevance 0.48
As discussed, many of the most crucial members of apoptotic pathways for these organ sites can be targeted MMR-deficient mutation, most notably BAX, APAF-1, BCL10, CASP-5, FAS and others (105).
Gene_expression (mutation) of MMR-deficient associated with apoptosis
3) Confidence 0.33 Published 2006 Journal Nucleic Acids Research Section Body Doc Link PMC1361617 Disease Relevance 0.76 Pain Relevance 0
Determinants of MR
Spec (Determinants) Gene_expression (Determinants) of MR
4) Confidence 0.29 Published 2006 Journal J Neuroengineering Rehabil Section Body Doc Link PMC1557523 Disease Relevance 0 Pain Relevance 0
In MMR-deficient mouse model experiments, Pten, a gene mutated also in human MMR defective cancers (103), was shown to be an important target whose mutation increases endometrial cancer rates (160).
Gene_expression (defective) of MMR associated with cancer and endometrial cancer
5) Confidence 0.29 Published 2006 Journal Nucleic Acids Research Section Body Doc Link PMC1361617 Disease Relevance 0.94 Pain Relevance 0
Other approaches have (102) used comprehensive literature search to identify 169 coding and 25 non-coding repeat sequences in colon, gastric and endometrial cancer and a cumulative mutation model to predict the genes with the strongest evidence for involvement in MMR defective mechanisms of carcinogenesis in the colon.
Gene_expression (defective) of MMR in colon associated with endometrial cancer
6) Confidence 0.29 Published 2006 Journal Nucleic Acids Research Section Body Doc Link PMC1361617 Disease Relevance 0.41 Pain Relevance 0
These results suggest that MMR deficiency can accelerate myeloid leukemogenesis in Nf1+/?
Gene_expression (deficiency) of MMR
7) Confidence 0.29 Published 2006 Journal Nucleic Acids Research Section Body Doc Link PMC1361617 Disease Relevance 0.81 Pain Relevance 0.03
Target genes in tumors from germline recessive versus sporadically acquired MMR deficiency
Gene_expression (deficiency) of MMR in germline associated with cancer
8) Confidence 0.29 Published 2006 Journal Nucleic Acids Research Section Body Doc Link PMC1361617 Disease Relevance 1.10 Pain Relevance 0
R2) adenine repeat frameshift mutations that occur at high rates in MMR defective cells, the combination of these two events may explain in part why GI epithelial cells are preferentially transformed in HNPCC.
Gene_expression (defective) of MMR in epithelial cells
9) Confidence 0.29 Published 2006 Journal Nucleic Acids Research Section Body Doc Link PMC1361617 Disease Relevance 0.64 Pain Relevance 0
Tissue specificity of apoptosis mechanisms in MMR defective cancers
Gene_expression (cancers) of MMR associated with cancer and apoptosis
10) Confidence 0.29 Published 2006 Journal Nucleic Acids Research Section Body Doc Link PMC1361617 Disease Relevance 1.32 Pain Relevance 0
Mr2096 and Mr2097 respectively produced analgesia and hyperalgesia in these strains of mice.
Gene_expression (produced) of Mr2097 associated with hyperalgesia, sprains and strains and analgesia
11) Confidence 0.22 Published 1985 Journal Jpn. J. Pharmacol. Section Abstract Doc Link 2987591 Disease Relevance 0.71 Pain Relevance 0.48
By this route, acute phase replication at 9 dpi was nearly undetectable compared to WT or MR, yet these altered kinetics did not substantially affect the establishment of latency in the PEC or splenocytes by the I?
Gene_expression (undetectable) of MR
12) Confidence 0.18 Published 2007 Journal PLoS Pathogens Section Body Doc Link PMC1781481 Disease Relevance 0.11 Pain Relevance 0
For example, within the spinal cord, two functionally distinct populations of macrophages have been identified: M1 macrophages that express markers including iNOS, CD86 and MHCII and have a neurotoxic function and M2 macrophages that express Arginase I and CD206 and have a neurotrophic role [7].
Gene_expression (express) of CD206 in macrophages associated with spinal cord
13) Confidence 0.15 Published 2010 Journal J Neuroinflammation Section Body Doc Link PMC2891720 Disease Relevance 1.19 Pain Relevance 0.38
Using dissociated hippocampal cells to visualize AMPA receptor trafficking, the latter authors observed increased synaptic surface expression of GluR2 subunits of the AMPA receptor within minutes of exposure to corticosterone, BSA-conjugated corticosterone or aldosterone (the prototypic nMR agonist).
Gene_expression (expression) of nMR associated with agonist
14) Confidence 0.08 Published 2010 Journal Mol Brain Section Body Doc Link PMC2841592 Disease Relevance 0.07 Pain Relevance 0.13
Both of these receptors are present in the brain; while GR are expressed ubiquitously (most strongly in the hippocampus), MR are more discretely distributed (strongly expressed in certain hippocampal subfields and the septum, and moderately expressed in the amygdala and hypothalamic paraventricular nucleus) [21].
Gene_expression (expressed) of MR in amygdala associated with hippocampus and amygdala
15) Confidence 0.08 Published 2010 Journal Mol Brain Section Body Doc Link PMC2841592 Disease Relevance 0.46 Pain Relevance 0.25
Both of these receptors are present in the brain; while GR are expressed ubiquitously (most strongly in the hippocampus), MR are more discretely distributed (strongly expressed in certain hippocampal subfields and the septum, and moderately expressed in the amygdala and hypothalamic paraventricular nucleus) [21].
Gene_expression (expressed) of MR in amygdala associated with hippocampus and amygdala
16) Confidence 0.08 Published 2010 Journal Mol Brain Section Body Doc Link PMC2841592 Disease Relevance 0.46 Pain Relevance 0.25
Of note, mineralocorticoid receptor (MR) gene expression is also affected by chronic antidepressant treatment in rats (Brady et al 1991), and MR function has also been linked to the pathophysiology of depression (Young et al 2003).


Gene_expression (expression) of MR associated with antidepressant and depression
17) Confidence 0.08 Published 2005 Journal Neuropsychiatric Disease and Treatment Section Body Doc Link PMC2426818 Disease Relevance 0.75 Pain Relevance 0.51
We also observed CD11c adjacent to mannose receptor and CD68 positive cells within the vasculature of TGRUN.
Gene_expression (adjacent) of mannose receptor in vasculature
18) Confidence 0.08 Published 2008 Journal J Neuroinflammation Section Body Doc Link PMC2329612 Disease Relevance 0.07 Pain Relevance 0
As this, some other effects of IL-4 are stimulating, in that it furthermore activates other Th2-like effects such as B cell class-switching and expression of mannose receptor and Fc receptor for IgE on macrophages [276].
Gene_expression (expression) of mannose receptor in macrophages
19) Confidence 0.02 Published 2005 Journal Virol J Section Body Doc Link PMC1215526 Disease Relevance 0.57 Pain Relevance 0.17

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