INT329061

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Context Info
Confidence 0.47
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 2
Disease Relevance 2.05
Pain Relevance 0.29

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endosome (Tlr9) endoplasmic reticulum (Tlr9) plasma membrane (Tlr9)
cellular_component (Tlr9) lysosome (Tlr9) cytoplasm (Tlr9)
Tlr9 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Inflammation 22 98.56 Very High Very High Very High
cytokine 12 98.04 Very High Very High Very High
Inflammatory response 2 86.00 High High
Inflammatory marker 2 80.00 Quite High
fifth nerve 6 40.24 Quite Low
trigeminal ganglion 4 5.00 Very Low Very Low Very Low
isoflurane 4 5.00 Very Low Very Low Very Low
Central nervous system 2 5.00 Very Low Very Low Very Low
anesthesia 2 5.00 Very Low Very Low Very Low
Inflammatory mediators 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
INFLAMMATION 28 98.56 Very High Very High Very High
Cold Sores 122 97.84 Very High Very High Very High
Viral Meningitis 64 87.68 High High
Sprains And Strains 94 87.44 High High
Infection 58 85.44 High High
Recurrence 2 71.40 Quite High
Disease 8 70.36 Quite High
Necrosis 2 67.12 Quite High
Focal Infection 2 66.04 Quite High
Herpes Simplex Virus 8 53.52 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Dependent on the signaling cascade that is activated upon Tlr9 binding, type I interferons or pro-inflammatory cytokines will be produced.
Positive_regulation (activated) of Tlr9 associated with inflammation and cytokine
1) Confidence 0.47 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2929186 Disease Relevance 1.43 Pain Relevance 0.17
Low Tlr2 and Tlr9 mRNA expression in the susceptible DA rats
Positive_regulation (Low) of Tlr9
2) Confidence 0.21 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2929186 Disease Relevance 0.61 Pain Relevance 0.11

General Comments

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