INT329066

Context Info Confidence 0.43 First Reported 2010 Last Reported 2010 Negated 0 Speculated 0 Reported most in Body Documents 1 Total Number 2 Disease Relevance 1.12 Pain Relevance 0.08

intracellular (Tlr3) cytoplasm (Tlr3)

Anatomy Link Frequency whiskers 4 Tlr3 (Rattus norvegicus)

Pain Link Frequency Relevance Heat Inflammation 22 81.60 Inflammatory mediators 2 78.76 Central nervous system 2 20.68 cytokine 12 6.88 fifth nerve 6 5.00 trigeminal ganglion 4 5.00 isoflurane 4 5.00 anesthesia 2 5.00 Inflammatory marker 2 5.00 Inflammatory response 2 5.00

Disease Link Frequency Relevance Heat Viral Meningitis 64 99.80 INFLAMMATION 28 81.96 Cold Sores 122 74.96 Sprains And Strains 94 69.92 Viral Infection 2 65.44 Infection 58 63.84 Herpes Simplex Virus 8 50.00 Disease 8 5.00 Peripheral Arterial Disease 6 5.00 Targeted Disruption 4 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

The levels of Tlr3 were increased at 12 hpi and 1 dpi in the whiskers area of the DA rats, while differences were significant also at later time points in PVG rats.

Positive_regulation (increased) of Gene_expression (levels) of Tlr3 in whiskers

1) Confidence 0.43 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2929186 Disease Relevance 0.33 Pain Relevance 0.04

However, in our HSE model an elevated expression of Tlr3 in the whiskers area was seen in the susceptible rat and we hypothesized that the susceptibility was not caused by low expression of Tlr3.

Positive_regulation (elevated) of Gene_expression (expression) of Tlr3 in whiskers associated with viral meningitis

2) Confidence 0.43 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2929186 Disease Relevance 0.80 Pain Relevance 0.04

General Comments

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