INT329102

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Context Info
Confidence 0.04
First Reported 2010
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 0.92
Pain Relevance 0.04

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (CD4, HLA-DQA2) endosome (HLA-DQA2) signal transduction (CD4)
Golgi apparatus (HLA-DQA2) endoplasmic reticulum (HLA-DQA2) cell adhesion (CD4)
Anatomy Link Frequency
melanocyte 1
CD4 (Homo sapiens)
HLA-DQA2 (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammation 1 77.56 Quite High
Pain 2 5.00 Very Low Very Low Very Low
corticosteroid 1 5.00 Very Low Very Low Very Low
cytokine 1 5.00 Very Low Very Low Very Low
ketamine 1 5.00 Very Low Very Low Very Low
Buprenorphine 1 5.00 Very Low Very Low Very Low
analgesia 1 5.00 Very Low Very Low Very Low
imagery 1 5.00 Very Low Very Low Very Low
cva 1 5.00 Very Low Very Low Very Low
Potency 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Hypopigmentation 14 97.68 Very High Very High Very High
Cancer 29 82.40 Quite High
INFLAMMATION 1 77.56 Quite High
Acquired Immune Deficiency Syndrome Or Hiv Infection 26 57.36 Quite High
Melanoma 27 50.00 Quite Low
Sprains And Strains 2 49.20 Quite Low
Infection 19 46.60 Quite Low
Cytomegalovirus Infection 8 5.00 Very Low Very Low Very Low
Disease 5 5.00 Very Low Very Low Very Low
Pain 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Antiviral therapies targeted at CD4 can potentially have an undesired immunomodulatory effect, by either signaling through CD4 or blocking the interactions with MHC class II.
CD4 Binding (interactions) of MHC class II
1) Confidence 0.04 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2929209 Disease Relevance 0.16 Pain Relevance 0
The dendritic cells might have accumulated to the site of immune response, engulfed resulting damaged cells, and induced the promotion of CD4+ T-cells, which cannot recognize class I restricted peptide, but can recognize the melanocyte antigens presented on MHC-class II [42].
CD4 Neg (cannot) Binding (recognize) of MHC-class II in melanocyte
2) Confidence 0.03 Published 2010 Journal J Transl Med Section Body Doc Link PMC2949666 Disease Relevance 0.76 Pain Relevance 0.04

General Comments

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