INT329116

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Context Info
Confidence 0.38
First Reported 2010
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 1
Total Number 4
Disease Relevance 1.30
Pain Relevance 0.44

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell proliferation (LGI1) signal transduction (CNTNAP2) extracellular space (LGI1)
extracellular region (LGI1) cell adhesion (CNTNAP2) Golgi apparatus (CNTNAP2)
Anatomy Link Frequency
brain 1
hippocampus 1
LGI1 (Homo sapiens)
CNTNAP2 (Homo sapiens)
Pain Link Frequency Relevance Heat
Hippocampus 28 98.12 Very High Very High Very High
potassium channel 332 98.00 Very High Very High Very High
hyperexcitability 8 89.76 High High
Pyramidal cell 8 81.76 Quite High
Sciatic nerve 16 40.00 Quite Low
Pain 16 5.00 Very Low Very Low Very Low
Neuropathic pain 8 5.00 Very Low Very Low Very Low
imagery 8 5.00 Very Low Very Low Very Low
Central nervous system 4 5.00 Very Low Very Low Very Low
Inflammation 4 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Limbic Encephalitis 108 91.60 High High
Syndrome 176 90.16 High High
Epilepsy 64 89.76 High High
Cancer 76 88.00 High High
Cognitive Disorder 8 87.84 High High
Isaacs Syndrome 100 79.36 Quite High
Thymoma 28 77.28 Quite High
Death 12 77.00 Quite High
Glioma 24 50.00 Quite Low
Targeted Disruption 8 18.24 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In the CA3 area of the hippocampus, Caspr2 (A and B) is strongly expressed in the stratum radiatum (rad), whereas Kv1.1 (A) and Lgi1 (B) are most prominent in the mossy fibre layer (mf) where Caspr2 is almost absent.
Lgi1 Neg (absent) Binding (absent) of Caspr2 in hippocampus associated with hippocampus
1) Confidence 0.38 Published 2010 Journal Brain Section Body Doc Link PMC2929337 Disease Relevance 0.12 Pain Relevance 0.21
Using polyethylenimine, cells were transiently co-transfected with plasmids containing Kv1.1, 1.2 and 1.6, EGFP, MuSK-EGFP, Caspr2-EGFP, Lgi1, contactin-2 cDNA (kind gift of Dr Karagogeos, University of Crete, Greece) or Lgi1 fused to Caspr2.


Lgi1 Binding (fused) of Caspr2
2) Confidence 0.38 Published 2010 Journal Brain Section Body Doc Link PMC2929337 Disease Relevance 0 Pain Relevance 0.05
Using polyethylenimine, cells were transiently co-transfected with plasmids containing Kv1.1, 1.2 and 1.6, EGFP, MuSK-EGFP, Caspr2-EGFP, Lgi1, contactin-2 cDNA (kind gift of Dr Karagogeos, University of Crete, Greece) or Lgi1 fused to Caspr2.


Lgi1 Binding (fused) of Caspr2
3) Confidence 0.38 Published 2010 Journal Brain Section Body Doc Link PMC2929337 Disease Relevance 0 Pain Relevance 0.05
Here, we show that the majority of VGKC-antibodies of high titre are not directed towards the Kv1 subunits themselves but to two proteins, Lgi1 and Caspr2, that are closely associated with VGKCs in brain tissue and remain complexed with the VGKCs in 2% digitonin extracts.
Lgi1 Binding (complexed) of Caspr2 in brain associated with potassium channel
4) Confidence 0.37 Published 2010 Journal Brain Section Body Doc Link PMC2929337 Disease Relevance 1.18 Pain Relevance 0.13

General Comments

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