INT329120

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Context Info
Confidence 0.09
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 4
Disease Relevance 1.23
Pain Relevance 0.75

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (CNTNAP2) cell adhesion (CNTNAP2) Golgi apparatus (CNTNAP2)
plasma membrane (KCNA1) enzyme binding (CNTNAP2) transmembrane transport (KCNA1)
Anatomy Link Frequency
peripheral nerves 2
brain 1
neural 1
KCNA1 (Homo sapiens)
CNTNAP2 (Homo sapiens)
Pain Link Frequency Relevance Heat
potassium channel 332 99.52 Very High Very High Very High
Hippocampus 28 91.56 High High
Pain 16 60.56 Quite High
Sciatic nerve 16 5.00 Very Low Very Low Very Low
hyperexcitability 8 5.00 Very Low Very Low Very Low
Neuropathic pain 8 5.00 Very Low Very Low Very Low
Pyramidal cell 8 5.00 Very Low Very Low Very Low
imagery 8 5.00 Very Low Very Low Very Low
Central nervous system 4 5.00 Very Low Very Low Very Low
Inflammation 4 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Syndrome 176 71.72 Quite High
Limbic Encephalitis 108 70.84 Quite High
Sleep Disorders 32 61.96 Quite High
Pain 16 60.56 Quite High
Isaacs Syndrome 100 59.24 Quite High
Glioma 24 50.00 Quite Low
Cancer 76 42.44 Quite Low
Disease 12 29.08 Quite Low
Epilepsy 64 11.04 Low Low
Thymoma 28 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Whereas Caspr2 is strongly associated with Kv1.1 and Kv1.2 at juxtaparanodes (Poliak et al., 2003), Lgi1 expression in peripheral nerves is weak but present (Ogawa et al., 2010; KA Kleopa, unpublished data).
Kv1 Binding (associated) of Caspr2 in peripheral nerves
1) Confidence 0.09 Published 2010 Journal Brain Section Body Doc Link PMC2929337 Disease Relevance 0.62 Pain Relevance 0.24
Whereas Caspr2 is strongly associated with Kv1.1 and Kv1.2 at juxtaparanodes (Poliak et al., 2003), Lgi1 expression in peripheral nerves is weak but present (Ogawa et al., 2010; KA Kleopa, unpublished data).
Kv1 Binding (associated) of Caspr2 in peripheral nerves
2) Confidence 0.09 Published 2010 Journal Brain Section Body Doc Link PMC2929337 Disease Relevance 0.62 Pain Relevance 0.24
-DTX labelled rabbit brain Kv1s indicating that Lgi1, Caspr2 and contactin-2 were complexed with the Kv1s.
Kv1s Binding (complexed) of Caspr2 in brain
3) Confidence 0.09 Published 2010 Journal Brain Section Body Doc Link PMC2929337 Disease Relevance 0 Pain Relevance 0.14
Caspr2 co-localizes with Kv1.1 and 1.2 at neural juxtaparanodes, is essential for VGKC clustering in vivo (Poliak et al., 2003), and has a large extracellular sequence.
Kv1 Binding (localizes) of Caspr2 in neural associated with potassium channel
4) Confidence 0.07 Published 2010 Journal Brain Section Body Doc Link PMC2929337 Disease Relevance 0 Pain Relevance 0.14

General Comments

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