INT329122

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Context Info
Confidence 0.08
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 2
Disease Relevance 0.29
Pain Relevance 0.43

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell proliferation (LGI1) extracellular space (LGI1) extracellular region (LGI1)
plasma membrane (KCNA1) transmembrane transport (KCNA1)
Anatomy Link Frequency
neuronal 1
brain 1
KCNA1 (Homo sapiens)
LGI1 (Homo sapiens)
Pain Link Frequency Relevance Heat
potassium channel 166 99.52 Very High Very High Very High
Multiple sclerosis 2 72.68 Quite High
Hippocampus 14 5.00 Very Low Very Low Very Low
Pain 8 5.00 Very Low Very Low Very Low
Sciatic nerve 8 5.00 Very Low Very Low Very Low
hyperexcitability 4 5.00 Very Low Very Low Very Low
Neuropathic pain 4 5.00 Very Low Very Low Very Low
Pyramidal cell 4 5.00 Very Low Very Low Very Low
imagery 4 5.00 Very Low Very Low Very Low
Central nervous system 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Thymoma 14 73.72 Quite High
Demyelinating Disease 4 72.68 Quite High
Neurological Disease 2 71.32 Quite High
Disease 6 70.96 Quite High
Syndrome 88 50.00 Quite Low
Limbic Encephalitis 54 50.00 Quite Low
Glioma 12 50.00 Quite Low
Isaacs Syndrome 50 5.00 Very Low Very Low Very Low
Cancer 38 5.00 Very Low Very Low Very Low
Epilepsy 32 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
-DTX labelled rabbit brain Kv1s indicating that Lgi1, Caspr2 and contactin-2 were complexed with the Kv1s.
Kv1s Binding (complexed) of Lgi1 in brain
1) Confidence 0.08 Published 2010 Journal Brain Section Body Doc Link PMC2929337 Disease Relevance 0 Pain Relevance 0.14
Lgi1 associates specifically with Kv1.1 subunits in CNS presynaptic terminals (Schulte et al., 2006), and is a secreted protein that can associate with neuronal and non-neuronal cell membranes (Sireol-Piquer et al., 2006).
Kv1 Binding (associates) of Lgi1 in neuronal
2) Confidence 0.08 Published 2010 Journal Brain Section Body Doc Link PMC2929337 Disease Relevance 0.29 Pain Relevance 0.29

General Comments

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