INT329140

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Context Info
Confidence 0.73
First Reported 2010
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 1
Total Number 4
Disease Relevance 3.56
Pain Relevance 1.31

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (CNTNAP2) cell adhesion (CNTNAP2) Golgi apparatus (CNTNAP2)
enzyme binding (CNTNAP2)
Anatomy Link Frequency
hippocampus 2
cerebellum 1
CNTNAP2 (Homo sapiens)
Pain Link Frequency Relevance Heat
Hippocampus 28 100.00 Very High Very High Very High
potassium channel 332 99.52 Very High Very High Very High
Sciatic nerve 16 87.68 High High
Pain 16 77.24 Quite High
Pyramidal cell 8 58.92 Quite High
hyperexcitability 8 5.00 Very Low Very Low Very Low
Neuropathic pain 8 5.00 Very Low Very Low Very Low
imagery 8 5.00 Very Low Very Low Very Low
Central nervous system 4 5.00 Very Low Very Low Very Low
Inflammation 4 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Glioma 24 97.48 Very High Very High Very High
Targeted Disruption 8 90.44 High High
Syndrome 176 88.40 High High
Limbic Encephalitis 108 87.52 High High
Endometriosis (extended) 12 81.68 Quite High
Thymoma 28 80.00 Quite High
Sleep Disorders 32 78.64 Quite High
Pain 16 77.24 Quite High
Cancer 76 76.00 Quite High
Isaacs Syndrome 100 75.92 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Having identified the true targets for the antibodies in these patients, it appears that these results were confounded by the very similar localization of Lgi1 and Kv1.1, particularly in the hippocampus, and of Caspr2 and Kv1.2 (Kv1.2 not shown here but can be seen in Kleopa et al., 2006), both in the hippocampus and cerebellum.
Localization (confounded) of Caspr2 in hippocampus associated with hippocampus
1) Confidence 0.73 Published 2010 Journal Brain Section Body Doc Link PMC2929337 Disease Relevance 1.03 Pain Relevance 0.31
-dendrotoxin-labelled potassium channels in brain extracts: (i) contactin-associated protein-2 that is localized at the juxtaparanodes in myelinated axons; (ii) leucine-rich, glioma inactivated 1 protein that is most strongly expressed in the hippocampus; and (iii) Tag-1/contactin-2 that associates with contactin-associated protein-2.
Localization (localized) of contactin-associated protein-2 in hippocampus associated with hippocampus, potassium channel and glioma
2) Confidence 0.73 Published 2010 Journal Brain Section Abstract Doc Link PMC2929337 Disease Relevance 1.07 Pain Relevance 0.40
The remaining six sera (two VGKC-antibody positive and four controls) did not show clear localization with either Lgi1 or Caspr2.
Spec (clear) Localization (localization) of Caspr2 associated with potassium channel
3) Confidence 0.69 Published 2010 Journal Brain Section Body Doc Link PMC2929337 Disease Relevance 0.43 Pain Relevance 0.28
Having identified the true targets for the antibodies in these patients, it appears that these results were confounded by the very similar localization of Lgi1 and Kv1.1, particularly in the hippocampus, and of Caspr2 and Kv1.2 (Kv1.2 not shown here but can be seen in Kleopa et al., 2006), both in the hippocampus and cerebellum.
Localization (confounded) of Caspr2 in cerebellum associated with hippocampus
4) Confidence 0.25 Published 2010 Journal Brain Section Body Doc Link PMC2929337 Disease Relevance 1.03 Pain Relevance 0.31

General Comments

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