INT329143

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Context Info
Confidence 0.47
First Reported 2010
Last Reported 2010
Negated 2
Speculated 0
Reported most in Body
Documents 1
Total Number 9
Disease Relevance 5.04
Pain Relevance 1.32

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (CNTNAP2) cell adhesion (CNTNAP2) Golgi apparatus (CNTNAP2)
enzyme binding (CNTNAP2)
Anatomy Link Frequency
brain 2
autonomic 1
hippocampus 1
CNTNAP2 (Homo sapiens)
Pain Link Frequency Relevance Heat
Hippocampus 63 99.74 Very High Very High Very High
potassium channel 747 97.82 Very High Very High Very High
Neuropathic pain 18 95.00 High High
hyperexcitability 18 89.40 High High
Sciatic nerve 36 74.28 Quite High
Pyramidal cell 18 24.96 Low Low
Multiple sclerosis 9 9.52 Low Low
Pain 36 5.00 Very Low Very Low Very Low
imagery 18 5.00 Very Low Very Low Very Low
Central nervous system 9 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Glioma 54 100.00 Very High Very High Very High
Syndrome 396 96.04 Very High Very High Very High
Isaacs Syndrome 225 95.60 Very High Very High Very High
Neuropathic Pain 18 95.00 High High
Cancer 171 93.48 High High
Targeted Disruption 18 92.36 High High
Limbic Encephalitis 243 91.60 High High
Epilepsy 144 89.76 High High
Cognitive Disorder 18 87.48 High High
Sleep Disorders 72 84.32 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Surprisingly, only a few patients had antibodies binding to the Kv1 subunits themselves but most bound only to one of two proteins, leucine-rich glioma inactivated 1 (Lgi1) or contactin-associated protein-2 (Caspr2), that are part of the ?
Caspr2 Binding (bound) of associated with glioma
1) Confidence 0.47 Published 2010 Journal Brain Section Body Doc Link PMC2929337 Disease Relevance 0.55 Pain Relevance 0.15
It is likely that binding of Caspr2 antibodies results in down-regulation of Caspr2/Kv1.1/1.2 complexes on the peripheral nerve axon, leading to neuromyotonia, neuropathic pain and autonomic dysfunction.
Caspr2 Binding (binding) of in autonomic associated with isaacs syndrome and neuropathic pain
2) Confidence 0.47 Published 2010 Journal Brain Section Body Doc Link PMC2929337 Disease Relevance 0.77 Pain Relevance 0.13
Five sera bound to contactin-2 itself but four of these sera also bound to Kv1, Caspr2 or Lgi1.


Caspr2 Binding (bound) of
3) Confidence 0.37 Published 2010 Journal Brain Section Body Doc Link PMC2929337 Disease Relevance 0.39 Pain Relevance 0.14
Surprisingly, only a few patients had antibodies binding to the Kv1 subunits themselves but most bound only to one of two proteins, leucine-rich glioma inactivated 1 (Lgi1) or contactin-associated protein-2 (Caspr2), that are part of the ?
contactin-associated protein-2 Binding (bound) of associated with glioma
4) Confidence 0.37 Published 2010 Journal Brain Section Body Doc Link PMC2929337 Disease Relevance 0.55 Pain Relevance 0.15
Nineteen of the VGKC-antibody positive sera (20%) at 1 : 100 dilution bound to the surface of these cells, and not to cells transfected with control vectors (data not shown); control sera did not bind Caspr2-transfected HEK293 cells (Fig. 3A).
Caspr2-transfected Neg (not) Binding (bind) of associated with potassium channel
5) Confidence 0.37 Published 2010 Journal Brain Section Body Doc Link PMC2929337 Disease Relevance 0 Pain Relevance 0.19
Here, we show that the majority of VGKC-antibodies of high titre are not directed towards the Kv1 subunits themselves but to two proteins, Lgi1 and Caspr2, that are closely associated with VGKCs in brain tissue and remain complexed with the VGKCs in 2% digitonin extracts.
Caspr2 Binding (associated) of in brain associated with potassium channel
6) Confidence 0.35 Published 2010 Journal Brain Section Body Doc Link PMC2929337 Disease Relevance 1.15 Pain Relevance 0.13
Here, we show that the majority of VGKC-antibodies of high titre are not directed towards the Kv1 subunits themselves but to two proteins, Lgi1 and Caspr2, that are closely associated with VGKCs in brain tissue and remain complexed with the VGKCs in 2% digitonin extracts.
Caspr2 Binding (complexed) of in brain associated with potassium channel
7) Confidence 0.35 Published 2010 Journal Brain Section Body Doc Link PMC2929337 Disease Relevance 1.18 Pain Relevance 0.13
Nine additional sera (one illustrated here) bound to these cells; but there was no binding of healthy control sera or Caspr2-antibody positive sera.
Caspr2 Neg (no) Binding (binding) of
8) Confidence 0.35 Published 2010 Journal Brain Section Body Doc Link PMC2929337 Disease Relevance 0.06 Pain Relevance 0.15
In the CA3 area of the hippocampus Serum 6 (A) binds strongly to the stratum radiatum (rad) where Caspr2 is prominently expressed (A) but not to the mossy fibre layer (mf) where Caspr2 is almost absent.
Caspr2 Binding (binds) of in hippocampus associated with hippocampus
9) Confidence 0.35 Published 2010 Journal Brain Section Body Doc Link PMC2929337 Disease Relevance 0.39 Pain Relevance 0.15

General Comments

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