INT329149

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Context Info
Confidence 0.73
First Reported 2010
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 1
Total Number 7
Disease Relevance 4.95
Pain Relevance 1.79

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell proliferation (LGI1) extracellular space (LGI1) extracellular region (LGI1)
Anatomy Link Frequency
hippocampus 2
neuronal 1
neurons 1
cerebellum 1
LGI1 (Homo sapiens)
Pain Link Frequency Relevance Heat
potassium channel 581 99.52 Very High Very High Very High
Hippocampus 49 98.72 Very High Very High Very High
Sciatic nerve 28 86.88 High High
Pain 28 76.00 Quite High
Multiple sclerosis 7 72.68 Quite High
Pyramidal cell 14 58.92 Quite High
hyperexcitability 14 5.00 Very Low Very Low Very Low
Neuropathic pain 14 5.00 Very Low Very Low Very Low
imagery 14 5.00 Very Low Very Low Very Low
Central nervous system 7 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Glioma 42 100.00 Very High Very High Very High
Limbic Encephalitis 189 99.64 Very High Very High Very High
Neuroblastoma 7 97.52 Very High Very High Very High
Epilepsy 112 93.08 High High
Targeted Disruption 14 90.44 High High
Syndrome 308 87.16 High High
Endometriosis (extended) 21 80.12 Quite High
Thymoma 49 78.44 Quite High
Disease 21 77.52 Quite High
Sleep Disorders 56 77.40 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Having identified the true targets for the antibodies in these patients, it appears that these results were confounded by the very similar localization of Lgi1 and Kv1.1, particularly in the hippocampus, and of Caspr2 and Kv1.2 (Kv1.2 not shown here but can be seen in Kleopa et al., 2006), both in the hippocampus and cerebellum.
Localization (localization) of Lgi1 in hippocampus associated with hippocampus
1) Confidence 0.73 Published 2010 Journal Brain Section Body Doc Link PMC2929337 Disease Relevance 0.96 Pain Relevance 0.31
This was explained by the fact that Lgi1 is secreted from neurons and can then bind to cell surfaces, as shown in neuroblastoma and COS7 cells (Sirerol-Piquer et al., 2006) and now demonstrated in HEK293 cells.
Localization (secreted) of Lgi1 in neurons associated with neuroblastoma
2) Confidence 0.73 Published 2010 Journal Brain Section Body Doc Link PMC2929337 Disease Relevance 0.54 Pain Relevance 0.09
It is notable that 91% of the Lgi1-antibody positive patients had limbic encephalitis, consistent with Lgi1’s hippocampal localization, and only one had peripheral symptoms.
Localization (localization) of Lgi1 associated with limbic encephalitis
3) Confidence 0.68 Published 2010 Journal Brain Section Body Doc Link PMC2929337 Disease Relevance 0.59 Pain Relevance 0.11
The remaining six sera (two VGKC-antibody positive and four controls) did not show clear localization with either Lgi1 or Caspr2.
Spec (clear) Localization (localization) of Lgi1 associated with potassium channel
4) Confidence 0.64 Published 2010 Journal Brain Section Body Doc Link PMC2929337 Disease Relevance 0.43 Pain Relevance 0.28
Lgi1 associates specifically with Kv1.1 subunits in CNS presynaptic terminals (Schulte et al., 2006), and is a secreted protein that can associate with neuronal and non-neuronal cell membranes (Sireol-Piquer et al., 2006).
Localization (secreted) of Lgi1 in neuronal
5) Confidence 0.64 Published 2010 Journal Brain Section Body Doc Link PMC2929337 Disease Relevance 0.30 Pain Relevance 0.29
-dendrotoxin-labelled potassium channels in brain extracts: (i) contactin-associated protein-2 that is localized at the juxtaparanodes in myelinated axons; (ii) leucine-rich, glioma inactivated 1 protein that is most strongly expressed in the hippocampus; and (iii) Tag-1/contactin-2 that associates with contactin-associated protein-2.
Localization (localized) of inactivated 1 in hippocampus associated with hippocampus, potassium channel and glioma
6) Confidence 0.59 Published 2010 Journal Brain Section Abstract Doc Link PMC2929337 Disease Relevance 1.17 Pain Relevance 0.40
Having identified the true targets for the antibodies in these patients, it appears that these results were confounded by the very similar localization of Lgi1 and Kv1.1, particularly in the hippocampus, and of Caspr2 and Kv1.2 (Kv1.2 not shown here but can be seen in Kleopa et al., 2006), both in the hippocampus and cerebellum.
Localization (localization) of Lgi1 in cerebellum associated with hippocampus
7) Confidence 0.25 Published 2010 Journal Brain Section Body Doc Link PMC2929337 Disease Relevance 0.96 Pain Relevance 0.31

General Comments

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