INT329156

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Context Info
Confidence 0.19
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 3
Disease Relevance 2.35
Pain Relevance 0.48

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (CNTNAP2) cell adhesion (CNTNAP2) Golgi apparatus (CNTNAP2)
enzyme binding (CNTNAP2)
Anatomy Link Frequency
autonomic 1
CNTNAP2 (Homo sapiens)
Pain Link Frequency Relevance Heat
potassium channel 249 99.08 Very High Very High Very High
Neuropathic pain 6 96.92 Very High Very High Very High
Hippocampus 21 5.00 Very Low Very Low Very Low
Pain 12 5.00 Very Low Very Low Very Low
Sciatic nerve 12 5.00 Very Low Very Low Very Low
hyperexcitability 6 5.00 Very Low Very Low Very Low
Pyramidal cell 6 5.00 Very Low Very Low Very Low
imagery 6 5.00 Very Low Very Low Very Low
Central nervous system 3 5.00 Very Low Very Low Very Low
Inflammation 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Isaacs Syndrome 75 98.16 Very High Very High Very High
Neuropathic Pain 6 96.92 Very High Very High Very High
Epilepsy 48 91.40 High High
Targeted Disruption 6 90.56 High High
Demyelinating Disease 6 89.76 High High
Sleep Disorders 24 88.16 High High
Cancer 57 85.12 High High
Syndrome 132 84.08 Quite High
Thymoma 21 80.48 Quite High
Cognitive Disorder 6 75.76 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
It is likely that binding of Caspr2 antibodies results in down-regulation of Caspr2/Kv1.1/1.2 complexes on the peripheral nerve axon, leading to neuromyotonia, neuropathic pain and autonomic dysfunction.
Regulation (regulation) of Caspr2 in autonomic associated with isaacs syndrome and neuropathic pain
1) Confidence 0.19 Published 2010 Journal Brain Section Body Doc Link PMC2929337 Disease Relevance 0.85 Pain Relevance 0.13
The targets for sera with lower VGKC antibodies should now be re-explored, but from our initial findings (unpublished observations) we anticipate that Kv1s, Caspr2 and contactin-2 will individually, or in combinations, prove to be targets in many patients with VGKC-antibody positive neuromyotonia, and also may be positive in some that are currently negative for VGKC-antibodies.
Regulation (targets) of Caspr2 associated with isaacs syndrome and potassium channel
2) Confidence 0.12 Published 2010 Journal Brain Section Body Doc Link PMC2929337 Disease Relevance 1.20 Pain Relevance 0.32
A patent has been filed by the University of Oxford claiming Caspr2, Lgi1 and Contactin-2 as targets for autoantibodies.


Regulation (targets) of Caspr2
3) Confidence 0.10 Published 2010 Journal Brain Section Body Doc Link PMC2929337 Disease Relevance 0.29 Pain Relevance 0.03

General Comments

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