INT329161

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Context Info
Confidence 0.42
First Reported 2010
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 1
Total Number 3
Disease Relevance 0.73
Pain Relevance 0.51

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (CNTNAP2) cell adhesion (CNTNAP2) Golgi apparatus (CNTNAP2)
enzyme binding (CNTNAP2)
Anatomy Link Frequency
brains 1
granule cell 1
hippocampus 1
CNTNAP2 (Homo sapiens)
Pain Link Frequency Relevance Heat
Hippocampus 21 99.28 Very High Very High Very High
potassium channel 249 98.80 Very High Very High Very High
Sciatic nerve 12 79.68 Quite High
Pyramidal cell 6 35.04 Quite Low
Pain 12 5.00 Very Low Very Low Very Low
hyperexcitability 6 5.00 Very Low Very Low Very Low
Neuropathic pain 6 5.00 Very Low Very Low Very Low
imagery 6 5.00 Very Low Very Low Very Low
Central nervous system 3 5.00 Very Low Very Low Very Low
Inflammation 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Syndrome 132 99.34 Very High Very High Very High
Limbic Encephalitis 81 82.80 Quite High
Targeted Disruption 6 51.24 Quite High
Glioma 18 50.00 Quite Low
Amnesia 12 14.40 Low Low
Confusion 12 13.68 Low Low
Convulsion 12 9.92 Low Low
Isaacs Syndrome 75 5.00 Very Low Very Low Very Low
Cancer 57 5.00 Very Low Very Low Very Low
Epilepsy 48 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In the CA3 area of the hippocampus Serum 6 (A) binds strongly to the stratum radiatum (rad) where Caspr2 is prominently expressed (A) but not to the mossy fibre layer (mf) where Caspr2 is almost absent.
Negative_regulation (absent) of Caspr2 in hippocampus associated with hippocampus
1) Confidence 0.42 Published 2010 Journal Brain Section Body Doc Link PMC2929337 Disease Relevance 0.36 Pain Relevance 0.17
In the cerebellum, Serum 6 (C) colocalizes with Caspr2 in the molecular (mol) and granule cell layers (GCL), but does not bind to the pinceau where Lgi1 is strongly expressed (red arrows in D) but Caspr2 is absent.
Negative_regulation (absent) of Caspr2 in granule cell
2) Confidence 0.42 Published 2010 Journal Brain Section Body Doc Link PMC2929337 Disease Relevance 0.26 Pain Relevance 0.11
To explore further the relationships between the two main antibody targets, the potassium channels and the clinical syndromes, we first examined the relative distribution of Lgi1, Caspr2 and Kv1.1 in the hippocampus and cerebellum of mouse brains.
Spec (examined) Negative_regulation (distribution) of Caspr2 in brains associated with syndrome, hippocampus and potassium channel
3) Confidence 0.42 Published 2010 Journal Brain Section Body Doc Link PMC2929337 Disease Relevance 0.10 Pain Relevance 0.23

General Comments

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