INT32923

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Context Info
Confidence 0.57
First Reported 1984
Last Reported 1985
Negated 0
Speculated 0
Reported most in Abstract
Documents 2
Total Number 3
Disease Relevance 0
Pain Relevance 2.38

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signal transduction (TRIM13) endoplasmic reticulum (TRIM13) intracellular (TRIM13)
ligase activity (TRIM13) cytoplasm (TRIM13) signal transducer activity (TRIM13)
TRIM13 (Homo sapiens)
Pain Link Frequency Relevance Heat
Enkephalin 13 100.00 Very High Very High Very High
agonist 5 100.00 Very High Very High Very High
Morphine 6 99.84 Very High Very High Very High
antagonist 1 95.56 Very High Very High Very High
opiate 8 94.76 High High
Opioid 7 91.60 High High

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Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Displacement curve analyses demonstrated that GTP and its nonhydrolyzable analog, GPP(NH)P, inhibited the binding of [3H]dihydromorphine (mu agonist), [3H]D-Ala2-D-Leu5-enkephalin (delta agonist), and [3H]ethylketocyclazocine (general agonist) but not [3H]diprenorphine (general antagonist).
Negative_regulation (inhibited) of Leu5 Binding (binding) of associated with antagonist, agonist and enkephalin
1) Confidence 0.57 Published 1985 Journal Brain Res. Bull. Section Abstract Doc Link 2988712 Disease Relevance 0 Pain Relevance 0.41
Similarly, morphine (1 nM) inhibited the higher-affinity binding of 3H-D-Ala2-D-Leu5-enkephalin to a greater extent than its lower-affinity binding component, consistent with a common high-affinity binding site for opiates and enkephalins.
Negative_regulation (inhibited) of Leu5 Binding (binding) of associated with opiate, enkephalin and morphine
2) Confidence 0.57 Published 1984 Journal Mol. Pharmacol. Section Abstract Doc Link 6323950 Disease Relevance 0 Pain Relevance 0.87
Both treatments also eliminated the ability of low morphine concentrations (less than 1 nM) to inhibit 3H-D-Ala2-D-Leu5-enkephalin binding and of low D-Ala2-D-Leu5-enkephalin concentrations (less than 1 nM) to inhibit [3H]dihydromorphine binding.
Negative_regulation (inhibit) of Leu5 Binding (binding) of associated with enkephalin and morphine
3) Confidence 0.42 Published 1984 Journal Mol. Pharmacol. Section Abstract Doc Link 6323950 Disease Relevance 0 Pain Relevance 1.10

General Comments

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