INT329297

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Context Info
Confidence 0.18
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 3
Disease Relevance 1.54
Pain Relevance 0.64

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleolus (Aff3) cell adhesion (Cd226) nucleus (Aff3)
Cd226 (Mus musculus)
Aff3 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
rheumatoid arthritis 84 97.00 Very High Very High Very High
abatacept 3 84.96 Quite High
Adalimumab 6 80.28 Quite High
Infliximab 9 79.72 Quite High
Etanercept 9 79.24 Quite High
Rheumatism 3 29.52 Quite Low
Inflammatory response 3 5.00 Very Low Very Low Very Low
Arthritis 3 5.00 Very Low Very Low Very Low
antagonist 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Rheumatoid Arthritis 87 97.00 Very High Very High Very High
Diabetes Mellitus 12 96.64 Very High Very High Very High
Disease 21 84.60 Quite High
Disease Susceptibility 3 77.24 Quite High
Necrosis 9 75.00 Quite High
Cancer 9 75.00 Quite High
Rheumatic Diseases 3 29.52 Quite Low
INFLAMMATION 3 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Two variants mapping to AFF3 and one to the CD226 locus demonstrated statistically significant evidence for association under an additive model (table 3) (AFF3: rs10865035, allele G coefficient ?
CD226 Binding (one) of AFF3
1) Confidence 0.18 Published 2010 Journal Annals of the Rheumatic Diseases Section Body Doc Link PMC2930850 Disease Relevance 0.14 Pain Relevance 0.07
However, the association of CD226 and AFF3 variants with the anti-TNF response is weak, and the addition of these markers into predictive models including clinical variables has only a modest effect, increasing the r2 value from 15.7% to 17.0%.
CD226 Binding (association) of AFF3
2) Confidence 0.18 Published 2010 Journal Annals of the Rheumatic Diseases Section Body Doc Link PMC2930850 Disease Relevance 0.55 Pain Relevance 0.24
In the combined analysis, SNPs mapping to AFF3 and CD226 had a statistically significant association with the response to anti-TNF treatment under an additive model.
CD226 Binding (association) of AFF3
3) Confidence 0.18 Published 2010 Journal Annals of the Rheumatic Diseases Section Abstract Doc Link PMC2930850 Disease Relevance 0.84 Pain Relevance 0.34

General Comments

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