INT329298

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Context Info
Confidence 0.58
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 0.17
Pain Relevance 0.13

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (AFF1)
Anatomy Link Frequency
lymphocytes 1
AFF1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammatory response 1 91.84 High High
antagonist 1 86.44 High High
rheumatoid arthritis 28 74.08 Quite High
Infliximab 3 35.40 Quite Low
Etanercept 3 34.60 Quite Low
Adalimumab 2 5.00 Very Low Very Low Very Low
abatacept 1 5.00 Very Low Very Low Very Low
Rheumatism 1 5.00 Very Low Very Low Very Low
Arthritis 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
INFLAMMATION 1 91.84 High High
Rheumatoid Arthritis 29 74.08 Quite High
Necrosis 3 50.00 Quite Low
Cancer 3 50.00 Quite Low
Disease 7 5.00 Very Low Very Low Very Low
Diabetes Mellitus 4 5.00 Very Low Very Low Very Low
Disease Susceptibility 1 5.00 Very Low Very Low Very Low
Rheumatic Diseases 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The gene, also known as AF4/FMR2, is preferentially expressed on lymphoid cells and encodes a family of transcription factors that are thought to be implicated in the function of the lymphoid system.27 We speculate that variation in AFF3 may lead to an upregulated inflammatory response by lymphocytes, resulting in more circulating proinflammatory molecules and leading to a reduced response to TNF antagonists; further studies will be required to explore this.
Gene_expression (expressed) of AF4 in lymphocytes associated with inflammatory response and antagonist
1) Confidence 0.58 Published 2010 Journal Annals of the Rheumatic Diseases Section Body Doc Link PMC2930850 Disease Relevance 0.17 Pain Relevance 0.13

General Comments

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