INT32933

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Context Info
Confidence 0.32
First Reported 1985
Last Reported 2010
Negated 5
Speculated 2
Reported most in Body
Documents 57
Total Number 59
Disease Relevance 10.58
Pain Relevance 4.03

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

small molecule metabolic process (GNAS) intracellular (GNAS) GTPase activity (GNAS)
transmembrane transport (GNAS) cytoplasm (GNAS) signal transducer activity (GNAS)
Anatomy Link Frequency
brain 3
myometrium 2
cerebellum 2
muscle 2
colon 2
GNAS (Homo sapiens)
Pain Link Frequency Relevance Heat
Nerve growth factor 29 100.00 Very High Very High Very High
withdrawal 1 99.48 Very High Very High Very High
medulla 28 99.14 Very High Very High Very High
Chronic pancreatitis 41 98.48 Very High Very High Very High
Opioid 2 98.04 Very High Very High Very High
Hippocampus 98 91.36 High High
Substantia nigra 14 91.28 High High
palliative 1 89.76 High High
addiction 7 89.56 High High
amygdala 43 89.36 High High
Disease Link Frequency Relevance Heat
Metastasis 11 99.98 Very High Very High Very High
Sprains And Strains 49 99.68 Very High Very High Very High
Adenocarcinoma 6 99.54 Very High Very High Very High
Disease 121 98.84 Very High Very High Very High
Pancreatitis 71 98.48 Very High Very High Very High
Familial Dysautonomia 121 97.80 Very High Very High Very High
Brain Tumor 4 97.48 Very High Very High Very High
Nicotine Addiction 368 96.64 Very High Very High Very High
Cancer 33 96.26 Very High Very High Very High
Cystitis 4 94.56 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The emulsion was prepared by mixing pieces of GSP and adenoviral vectors expressing recombinant beta-galactosidase (Ad.LacZ) or human hepatocyte growth factor (Ad.hHGF).
Gene_expression (expressing) of GSP in hepatocyte
1) Confidence 0.32 Published 2005 Journal Cancer Gene Ther. Section Abstract Doc Link 15578067 Disease Relevance 0.18 Pain Relevance 0.09
Exon VIII was not detected in any transcript other than the ones starting with exon V, pointing to a possible functional regulation between the usage of a certain promoter and subsequent splicing.
Neg (not) Gene_expression (detected) of Exon VIII
2) Confidence 0.11 Published 2007 Journal Genomics Section Body Doc Link PMC2568880 Disease Relevance 0 Pain Relevance 0
Human BDNF exon VIIIh, which is not linked to a separate promoter, is also not present in rodent BDNF.
Neg (not) Gene_expression (present) of exon
3) Confidence 0.11 Published 2007 Journal Genomics Section Body Doc Link PMC2568880 Disease Relevance 0 Pain Relevance 0
For example, antiBDNF transcripts with exon 10 were present in the colon and muscle, whereas transcripts with exon 9 were not expressed in these tissues.
Neg (not) Gene_expression (expressed) of exon in colon
4) Confidence 0.11 Published 2007 Journal Genomics Section Body Doc Link PMC2568880 Disease Relevance 0.05 Pain Relevance 0.07
Exon IXabcd mRNAs were expressed at relatively similar levels in all brain regions, with only infundibulum having very low expression levels.
Gene_expression (expressed) of Exon in brain
5) Confidence 0.10 Published 2007 Journal Genomics Section Body Doc Link PMC2568880 Disease Relevance 0.06 Pain Relevance 0.18
All intron–exon boundaries of the antiBDNF gene are consistent with the GU–AG consensus (Supplementary Table 2).
Gene_expression (boundaries) of exon
6) Confidence 0.10 Published 2007 Journal Genomics Section Body Doc Link PMC2568880 Disease Relevance 0 Pain Relevance 0
Fourth, in contrast to the rodent BDNF genes we found that exon VIII of the human BDNF is not used as a 5?
Neg (not) Gene_expression (used) of exon VIII
7) Confidence 0.10 Published 2007 Journal Genomics Section Body Doc Link PMC2568880 Disease Relevance 0 Pain Relevance 0
Exon IXabcd mRNAs were expressed at relatively similar levels in all brain regions, with only infundibulum having very low expression levels.
Gene_expression (expression) of Exon in brain
8) Confidence 0.10 Published 2007 Journal Genomics Section Body Doc Link PMC2568880 Disease Relevance 0.06 Pain Relevance 0.18
PCR products of locus gpsA from 2 strains (no. 37 and 70) were digested with DdeI (Promega, USA) and NcoI (NEB, England) respectively, as recommended by the manufacturer.
Gene_expression (products) of gpsA associated with sprains and strains
9) Confidence 0.09 Published 2010 Journal PLoS Neglected Tropical Diseases Section Body Doc Link PMC2907413 Disease Relevance 0.36 Pain Relevance 0
Notably, comparison of expression levels of individual transcripts in different brain areas indicated that BDNF exon II transcript levels were much higher in the cerebellum than in other brain areas.
Gene_expression (higher) of exon in cerebellum
10) Confidence 0.09 Published 2007 Journal Genomics Section Body Doc Link PMC2568880 Disease Relevance 0.06 Pain Relevance 0.19
All BDNF transcripts except the ones containing exons V and VII were expressed at high levels in the cerebellum and medulla, and all transcripts but those containing exon IXabcd were expressed at high levels in the infundibulum.
Gene_expression (expressed) of exon in medulla associated with medulla
11) Confidence 0.09 Published 2007 Journal Genomics Section Body Doc Link PMC2568880 Disease Relevance 0.09 Pain Relevance 0.21
High levels of transcripts containing exon VI were expressed also in the lung.
Gene_expression (expressed) of exon in lung
12) Confidence 0.09 Published 2007 Journal Genomics Section Body Doc Link PMC2568880 Disease Relevance 0 Pain Relevance 0.04
For example, antiBDNF transcripts with exon 10 were present in the colon and muscle, whereas transcripts with exon 9 were not expressed in these tissues.
Gene_expression (present) of exon in colon
13) Confidence 0.09 Published 2007 Journal Genomics Section Body Doc Link PMC2568880 Disease Relevance 0 Pain Relevance 0.07
The expression patterns of nerve growth factor inducible clone A (NGFI-A), secretogranin, post-synaptic density protein of 95 Kd (PSD-95), prodynorphin and proenkephalin mRNA were also analyzed using in situ hybridization, after the challenge with amphetamine.
Spec (analyzed) Gene_expression (expression) of secretogranin in nerve associated with nerve growth factor
14) Confidence 0.08 Published 2008 Journal Neuroscience Section Abstract Doc Link 18093743 Disease Relevance 0.07 Pain Relevance 0.16
The downregulation of Gnas gene expression may result in less mitogen-activated protein kinase/extracellular signal-regulated kinase signaling and ultimately a reduction in osteoclast proliferation and actin filament formation, resulting in decreased bone resorption.
Gene_expression (expression) of Gnas gene in osteoclast associated with hypercalcemia
15) Confidence 0.07 Published 2010 Journal Clin Interv Aging Section Body Doc Link PMC2946855 Disease Relevance 0.46 Pain Relevance 0
For example, antiBDNF transcripts with exon 10 were present in the colon and muscle, whereas transcripts with exon 9 were not expressed in these tissues.
Neg (not) Gene_expression (expressed) of exon in muscle
16) Confidence 0.04 Published 2007 Journal Genomics Section Body Doc Link PMC2568880 Disease Relevance 0.05 Pain Relevance 0.07
The evoked expression of the immediate early gene-encoded proteins c-Fos and Krox-24 was used to study activation of hindbrain neurons as a function of the development of cyclophosphamide (CP) cystitis in behaving rats.
Gene_expression (expression) of gene-encoded in neurons associated with cystitis
17) Confidence 0.04 Published 1996 Journal Exp Brain Res Section Abstract Doc Link 8801120 Disease Relevance 0.55 Pain Relevance 0.21
DNA from patients and their families was amplified using primers designed to amplify the 33 exons, including the intron-exon boundaries, of the NOTCH3 gene.
Gene_expression (boundaries) of exon
18) Confidence 0.03 Published 2007 Journal BMC Med Genet Section Body Doc Link PMC2190758 Disease Relevance 0.44 Pain Relevance 0.03
All BDNF transcripts except the ones containing exons V and VII were expressed at high levels in the cerebellum and medulla, and all transcripts but those containing exon IXabcd were expressed at high levels in the infundibulum.
Gene_expression (expressed) of exon in cerebellum associated with medulla
19) Confidence 0.03 Published 2007 Journal Genomics Section Body Doc Link PMC2568880 Disease Relevance 0.09 Pain Relevance 0.21
For example, antiBDNF transcripts with exon 10 were present in the colon and muscle, whereas transcripts with exon 9 were not expressed in these tissues.
Gene_expression (present) of exon in muscle
20) Confidence 0.03 Published 2007 Journal Genomics Section Body Doc Link PMC2568880 Disease Relevance 0 Pain Relevance 0.07

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