INT329473

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Context Info
Confidence 0.04
First Reported 2010
Last Reported 2010
Negated 1
Speculated 1
Reported most in Body
Documents 1
Total Number 3
Disease Relevance 0.10
Pain Relevance 0.13

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transport (SLC7A7) lyase activity (Ca2) protein complex assembly (SLC7A7)
response to stress (Ca2) cytoplasm (Ca2) transmembrane transport (SLC7A7)
Anatomy Link Frequency
endothelial cells 1
SLC7A7 (Homo sapiens)
Ca2 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
withdrawal 3 91.44 High High
Cannabinoid receptor 6 86.08 High High
agonist 24 83.00 Quite High
member 8 3 5.00 Very Low Very Low Very Low
Endocannabinoid 3 5.00 Very Low Very Low Very Low
antagonist 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Targeted Disruption 15 98.62 Very High Very High Very High
Increased Venous Pressure Under Development 3 19.20 Low Low
Cancer 6 5.00 Very Low Very Low Very Low
Hypertension 3 5.00 Very Low Very Low Very Low
Pressure And Volume Under Development 3 5.00 Very Low Very Low Very Low
Atherosclerosis 3 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Applying small interference RNA-mediated knock-down and transient overexpression, GPR55-dependent and -independent effects of LPI on cytosolic free Ca2+ concentration, membrane potential and transmembrane ion currents were studied in EA.hy296 cells.


LPI Neg (independent) Regulation (effects) of Ca2 associated with targeted disruption
1) Confidence 0.04 Published 2010 Journal British Journal of Pharmacology Section Abstract Doc Link PMC2931756 Disease Relevance 0.10 Pain Relevance 0.08
To evaluate the role of Ca2+ entry in the LPI-induced electrical responses, LPI was added either in nominal Ca2+-free or Ni2+-containing solution.
LPI Regulation (role) of Ca2
2) Confidence 0.04 Published 2010 Journal British Journal of Pharmacology Section Body Doc Link PMC2931756 Disease Relevance 0 Pain Relevance 0.05
Because little is known about the effects of LPI as a possible vascular signalling mediator on endothelial membrane potential, this study was designed to investigate the effects of LPI on intracellular Ca2+ concentration, membrane potential, and to explore the underlying ion conductance in endothelial cells.


LPI Spec (investigate) Regulation (effects) of Ca2 in endothelial cells
3) Confidence 0.04 Published 2010 Journal British Journal of Pharmacology Section Body Doc Link PMC2931756 Disease Relevance 0 Pain Relevance 0

General Comments

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