INT329474

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Context Info
Confidence 0.03
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 2
Disease Relevance 0.40
Pain Relevance 0.08

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transport (SLC7A7) lyase activity (Ca2) protein complex assembly (SLC7A7)
response to stress (Ca2) cytoplasm (Ca2) transmembrane transport (SLC7A7)
Anatomy Link Frequency
endothelial cells 1
SLC7A7 (Homo sapiens)
Ca2 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
agonist 16 99.18 Very High Very High Very High
antagonist 2 60.44 Quite High
Cannabinoid receptor 4 11.00 Low Low
Endocannabinoid 2 5.48 Low Low
member 8 2 5.00 Very Low Very Low Very Low
withdrawal 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Increased Venous Pressure Under Development 2 96.68 Very High Very High Very High
Hypertension 2 81.76 Quite High
Atherosclerosis 2 80.12 Quite High
Targeted Disruption 10 74.64 Quite High
Cancer 4 33.08 Quite Low
Pressure And Volume Under Development 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In contrast to other G protein-coupled receptor agonists in this cell type (Malli et al., 2007), LPI initiated a transient Ca2+ elevation even in the presence of extracellular Ca2+, which points to a limited activity of store-operated Ca2+ entry (SOCE).
LPI Binding (initiated) of Ca2 associated with agonist
1) Confidence 0.03 Published 2010 Journal British Journal of Pharmacology Section Body Doc Link PMC2931756 Disease Relevance 0.14 Pain Relevance 0.08
One of the less examined LPs is lysophosphatidylinositol (LPI), a glycerol-based LP that has recently been reported to specifically interact with the G-protein-coupled receptor 55 (GPR55) (Oka et al., 2007; Waldeck-Weiermair et al., 2008) that mediates a transient Ca2+ increase upon stimulation of endothelial cells with LPI (Henstridge et al., 2008; Lauckner et al., 2008; Waldeck-Weiermair et al., 2008).
LPI Binding (interact) of Ca2 in endothelial cells
2) Confidence 0.03 Published 2010 Journal British Journal of Pharmacology Section Body Doc Link PMC2931756 Disease Relevance 0.26 Pain Relevance 0

General Comments

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