INT329480

Context Info Confidence 0.03 First Reported 2010 Last Reported 2010 Negated 0 Speculated 0 Reported most in Body Documents 1 Total Number 1 Disease Relevance 0.71 Pain Relevance 0

signal transduction (TNFRSF11B, TNFSF10) extracellular region (TNFRSF11B, TNFSF10) extracellular space (TNFSF10) proteinaceous extracellular matrix (TNFRSF11B) extracellular matrix organization (TNFRSF11B) cell-cell signaling (TNFSF10)

TNFRSF11B (Homo sapiens) TNFSF10 (Homo sapiens)

Pain Link Frequency Relevance Heat cva 11 5.00 Potency 3 5.00 withdrawal 2 5.00 Bioavailability 2 5.00 tolerance 2 5.00 headache 2 5.00 cINOD 1 5.00 transdermal 1 5.00 addiction 1 5.00 Paracetamol 1 5.00

Disease Link Frequency Relevance Heat Hypercalcemia 22 97.32 Apoptosis 2 95.40 Necrosis 1 78.64 Cancer 2 78.28 Osteoporosis 80 69.04 Disorders Of Creatine Metabolism 2 60.52 Renal Failure 1 59.20 Alopecia 1 53.24 Postmenopausal Osteoporosis 13 50.00 Syndrome 5 45.08

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

However, because OPG also binds to the cytotoxic ligand TRAIL and other members of the TNF family, a specific fully human antibody against RANKL has been developed (Amgen).

OPG Binding (binds) of TRAIL

1) Confidence 0.03 Published 2010 Journal Osteoporos Int Section Body Doc Link PMC2931762 Disease Relevance 0.71 Pain Relevance 0

General Comments

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