INT329486

Context Info Confidence 0.18 First Reported 2010 Last Reported 2010 Negated 0 Speculated 0 Reported most in Body Documents 1 Total Number 2 Disease Relevance 0.71 Pain Relevance 0

signal transduction (TNFRSF11B) extracellular region (TNFRSF11B) proteinaceous extracellular matrix (TNFRSF11B) extracellular matrix organization (TNFRSF11B)

Anatomy Link Frequency osteoclasts 3 osteoblasts 1 TNFRSF11B (Homo sapiens)

Pain Link Frequency Relevance Heat cva 22 5.00 Potency 6 5.00 withdrawal 4 5.00 Bioavailability 4 5.00 tolerance 4 5.00 headache 4 5.00 cINOD 2 5.00 transdermal 2 5.00 addiction 2 5.00 Paracetamol 2 5.00

Disease Link Frequency Relevance Heat Hypercalcemia 44 95.12 Osteoporosis 160 75.52 Postmenopausal Osteoporosis 26 50.00 Hip Fractures 20 43.52 Kidney Stones 4 36.84 Bone Fracture 50 5.00 Breast Cancer 38 5.00 Stroke 22 5.00 Thrombosis Related Under Development 14 5.00 Osteoporotic Fractures 14 5.00

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Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

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Disease term

Other studies have demonstrated the involvement of the calcium-sensing receptor in the effects of strontium ranelate on osteoblasts, osteoclasts, and OPG/RANKL regulation [126].

Regulation (effects) of Regulation (regulation) of OPG in osteoclasts

1) Confidence 0.18 Published 2010 Journal Osteoporos Int Section Body Doc Link PMC2931762 Disease Relevance 0.36 Pain Relevance 0

Other studies have demonstrated the involvement of the calcium-sensing receptor in the effects of strontium ranelate on osteoblasts, osteoclasts, and OPG/RANKL regulation [126].

Regulation (effects) of in osteoblasts Regulation (regulation) of OPG in osteoclasts

2) Confidence 0.06 Published 2010 Journal Osteoporos Int Section Body Doc Link PMC2931762 Disease Relevance 0.36 Pain Relevance 0

General Comments

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