INT329487

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Context Info
Confidence 0.45
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 0.62
Pain Relevance 0.05

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (SOST) extracellular region (SOST) transcription factor binding (SOST)
SOST (Homo sapiens)
Pain Link Frequency Relevance Heat
antagonist 1 99.36 Very High Very High Very High
cva 11 5.00 Very Low Very Low Very Low
Potency 3 5.00 Very Low Very Low Very Low
withdrawal 2 5.00 Very Low Very Low Very Low
Bioavailability 2 5.00 Very Low Very Low Very Low
tolerance 2 5.00 Very Low Very Low Very Low
headache 2 5.00 Very Low Very Low Very Low
cINOD 1 5.00 Very Low Very Low Very Low
transdermal 1 5.00 Very Low Very Low Very Low
addiction 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Osteoporosis 80 98.98 Very High Very High Very High
Apoptosis 2 89.92 High High
Postmenopausal Osteoporosis 13 71.76 Quite High
Hypercalcemia 22 37.92 Quite Low
Bone Fracture 25 5.00 Very Low Very Low Very Low
Breast Cancer 19 5.00 Very Low Very Low Very Low
Stroke 11 5.00 Very Low Very Low Very Low
Hip Fractures 10 5.00 Very Low Very Low Very Low
Thrombosis Related Under Development 7 5.00 Very Low Very Low Very Low
Osteoporotic Fractures 7 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The molecular mechanisms underlying these anabolic effects are still poorly understood, but appear to include both direct actions on osteoblastic cells as well as indirect effects such as through stimulation of IGF-1 production and downregulation of sclerostin, a physiologic antagonist of the important anabolic Wnt-?
Positive_regulation (stimulation) of Negative_regulation (downregulation) of sclerostin associated with antagonist and osteoporosis
1) Confidence 0.45 Published 2010 Journal Osteoporos Int Section Body Doc Link PMC2931762 Disease Relevance 0.62 Pain Relevance 0.05

General Comments

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