INT329555

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Context Info
Confidence 0.25
First Reported 2010
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 1
Total Number 12
Disease Relevance 1.55
Pain Relevance 0.22

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleoplasm (ESRRA) nucleus (ESRRA) DNA binding (ESRRA)
ESRRA (Homo sapiens)
Pain Link Frequency Relevance Heat
ischemia 132 93.40 High High
agonist 12 83.44 Quite High
Angina 24 17.32 Low Low
Disease Link Frequency Relevance Heat
Coronary Artery Disease 48 93.40 High High
Diabetes Mellitus 576 92.04 High High
Cv Unclassified Under Development 84 90.80 High High
Disease 48 89.52 High High
Myocardial Infarction 24 85.20 High High
Syndrome 180 76.16 Quite High
Cardiovascular Disease 12 39.08 Quite Low
Cv General 3 Under Development 24 17.32 Low Low
Heart Disease 24 5.00 Very Low Very Low Very Low
Death 24 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The variant A probe competed less effectively for binding to the 32P-labelled wild-type sequence (IC50 of A probe 2.3-fold greater than G probe, P<0.05), demonstrating a lower affinity for ERR?
ERR Binding (affinity) of
1) Confidence 0.25 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2933242 Disease Relevance 0 Pain Relevance 0
We next examined relative ERR binding in EMSA studies performed with the same wild-type PPARA ?
ERR Spec (examined) Binding (binding) of
2) Confidence 0.22 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2933242 Disease Relevance 0 Pain Relevance 0
To determine whether the decrease in ERR binding afforded by the PPARA ?
ERR Binding (binding) of
3) Confidence 0.22 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2933242 Disease Relevance 0 Pain Relevance 0
To test ERR binding, a 49 bp double-stranded (ds) oligonucleotide was generated corresponding to the ‘wild-type’ form of PPARA ?
ERR Binding (binding) of
4) Confidence 0.22 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2933242 Disease Relevance 0 Pain Relevance 0
Electrophoretic mobility shift assays (EMSA) were performed to compare binding of recombinant ERR?
ERR Binding (recombinant) of
5) Confidence 0.19 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2933242 Disease Relevance 0 Pain Relevance 0
proteins between 32P-labeled PPARA and authentic, previously described ERR binding sequences [28].
ERR Binding (binding) of
6) Confidence 0.19 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2933242 Disease Relevance 0 Pain Relevance 0
These studies demonstrate that the variant PPARA promoter sequence exhibits diminished ERR binding and decreased ERR-mediated transcriptional activation, compared to the wild-type PPARA ?
ERR Binding (binding) of
7) Confidence 0.19 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2933242 Disease Relevance 0.23 Pain Relevance 0.04
Electrophoretic mobility shift assays (EMSA) were performed to compare binding of recombinant ERR?
ERR Binding (binding) of
8) Confidence 0.19 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2933242 Disease Relevance 0 Pain Relevance 0
The relative affinity of ERR?
ERR Binding (affinity) of
9) Confidence 0.19 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2933242 Disease Relevance 0 Pain Relevance 0
Our studies suggest that modified ERR binding is a mechanism for altered PPARA expression in the polymorphic promoter, but there is scant available data on factors that affect ERR?
ERR Binding (binding) of
10) Confidence 0.19 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2933242 Disease Relevance 0.79 Pain Relevance 0.09
54,642 G>A promoter polymorphism: The more common (in Caucasians) PPARA G promoter is more responsive to ERR, while the variant A promoter is less effective at binding ERR and is therefore resistant to ERR-mediated transcription.
ERR Binding (binding) of
11) Confidence 0.17 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2933242 Disease Relevance 0.54 Pain Relevance 0.09
The apparent binding of both ERR?
ERR Binding (binding) of
12) Confidence 0.17 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2933242 Disease Relevance 0 Pain Relevance 0

General Comments

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