INT329571

Context Info Confidence 0.11 First Reported 2010 Last Reported 2010 Negated 0 Speculated 0 Reported most in Body Documents 2 Total Number 2 Disease Relevance 0.40 Pain Relevance 0

mitochondrion (MAP2K1) Golgi apparatus (MAP2K1) cytoplasm (MAP2K1) cytosol (MAP2K1) signal transduction (MAP2K1) mitosis (MAP2K1)

MAP2K1 (Homo sapiens)

Pain Link Frequency Relevance Heat chemokine 5 5.00 Inflammation 5 5.00 cytokine 3 5.00 withdrawal 3 5.00 Inflammatory response 3 5.00 headache 2 5.00 colic 1 5.00

Disease Link Frequency Relevance Heat Apoptosis 2 81.92 Rheumatoid Arthritis 67 75.84 Neuroblastoma 44 71.04 Cancer 18 38.88 Malignant Neoplastic Disease 11 21.12 Infection 19 11.64 Sprains And Strains 26 5.00 Death 18 5.00 INFLAMMATION 8 5.00 Stress 3 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

However, equilibrium binding studies showed that U0126 and PD98059 bind to MEK1 at identical or overlapping sites [40].

MEK1 Binding (bind) of

1) Confidence 0.11 Published 2010 Journal Nutrition Research and Practice Section Body Doc Link PMC2933444 Disease Relevance 0.32 Pain Relevance 0

PD98059 is a selective inhibitor of MEK1 activation and the ERK cascade, as it binds to the inactive forms of MEK1 and prevents activation by upstream activators.

MEK1 Binding (binds) of

2) Confidence 0.05 Published 2010 Journal BMC Microbiol Section Body Doc Link PMC3022711 Disease Relevance 0.08 Pain Relevance 0

General Comments

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