INT32963

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Context Info
Confidence 0.29
First Reported 1985
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 3
Disease Relevance 2.48
Pain Relevance 0.84

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (GNRHR) signal transducer activity (GNRHR)
Anatomy Link Frequency
pituitary 2
GNRHR (Homo sapiens)
Pain Link Frequency Relevance Heat
Endogenous opioid 2 99.98 Very High Very High Very High
Opioid 2 98.32 Very High Very High Very High
Fibrositis 77 92.88 High High
opioid receptor 1 90.00 High High
narcan 3 87.60 High High
Lasting pain 2 36.44 Quite Low
depression 19 5.00 Very Low Very Low Very Low
Pain 4 5.00 Very Low Very Low Very Low
corticosteroid 1 5.00 Very Low Very Low Very Low
drug abuse 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Stress 17 99.62 Very High Very High Very High
Anovulation 13 97.18 Very High Very High Very High
Reprotox - General 1 7 94.08 High High
Chronic Fatigue Syndrome 67 93.20 High High
Fibromyalgia 77 92.88 High High
Eating Disorder 1 89.36 High High
Kallmann Syndrome 1 87.68 High High
Confusion 1 70.96 Quite High
Congenital Anomalies 8 61.72 Quite High
Depression 42 50.00 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
There is also evidence to implicate suprahypothalamic mechanism(s) that enhance endogenous opioid inhibition of secretion of gonadotropin-releasing hormone.
Negative_regulation (inhibition) of Localization (secretion) of gonadotropin-releasing hormone associated with endogenous opioid
1) Confidence 0.29 Published 1985 Journal Am. J. Obstet. Gynecol. Section Abstract Doc Link 2990210 Disease Relevance 0 Pain Relevance 0.49
There are three classes of anovulation, ie, WHO I, WHO II and WHO III.15–17 Women with WHO class I anovulation, which accounts for 10% of anovulatory women, have low or low–normal serum FSH concentrations and low serum estradiol concentrations due to decreased hypothalamic secretion of gonadotropin-releasing hormone (GnRH) or pituitary unresponsiveness to GnRH.
Negative_regulation (decreased) of Localization (secretion) of gonadotropin-releasing hormone in pituitary associated with anovulation
2) Confidence 0.23 Published 2010 Journal International Journal of Women's Health Section Body Doc Link PMC2971716 Disease Relevance 0.87 Pain Relevance 0
Stress has been shown to inhibit gonadotropin-releasing hormone and the pulsatile secretion of luteinizing hormone.
Negative_regulation (inhibit) of Localization (secretion) of gonadotropin-releasing hormone associated with stress
3) Confidence 0.14 Published 2004 Journal Arthritis Res Ther Section Body Doc Link PMC416440 Disease Relevance 1.61 Pain Relevance 0.35

General Comments

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