INT329771

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.36
First Reported 2010
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 1
Total Number 5
Disease Relevance 2.30
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (SMAD1) nucleoplasm (SMAD1) signal transduction (SMAD1)
homeostatic process (SMAD1) nucleus (SMAD1) intracellular (SMAD1)
SMAD1 (Homo sapiens)
Pain Link Frequency Relevance Heat
metalloproteinase 70 5.00 Very Low Very Low Very Low
cytokine 5 5.00 Very Low Very Low Very Low
chemokine 5 5.00 Very Low Very Low Very Low
Pain 5 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Reprotox - General 1 290 99.32 Very High Very High Very High
Adhesions 190 98.32 Very High Very High Very High
Cancer 510 91.36 High High
Metastasis 215 70.04 Quite High
Shock 5 44.88 Quite Low
Breast Cancer 110 5.00 Very Low Very Low Very Low
Apoptosis 105 5.00 Very Low Very Low Very Low
Pancreatic Cancer 35 5.00 Very Low Very Low Very Low
Colon Cancer 35 5.00 Very Low Very Low Very Low
Death 30 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
At this time, it is unclear whether the activation of Smad1 and FAK are due to genistein’s inhibition of MEK4 or via a different signaling mechanism
Spec (whether) Positive_regulation (activation) of Smad1
1) Confidence 0.36 Published 2010 Journal Cancer Metastasis Rev Section Body Doc Link PMC2933845 Disease Relevance 0.50 Pain Relevance 0
Conversely, genistein can activate Smad1 in a manner that is dependent on ALK-2 kinase activity, but that is independent of endoglin [159].
Positive_regulation (activate) of Smad1
2) Confidence 0.36 Published 2010 Journal Cancer Metastasis Rev Section Body Doc Link PMC2933845 Disease Relevance 0.47 Pain Relevance 0
Genistein also activates Smad1, which is activated by the endoglin signaling pathway, and causes decreased cell invasion.
Positive_regulation (activates) of Smad1
3) Confidence 0.36 Published 2010 Journal Cancer Metastasis Rev Section Body Doc Link PMC2933845 Disease Relevance 0.43 Pain Relevance 0
Smad1 is activated by the endoglin/ALK-2 signaling pathway and acts to suppress invasion.
Positive_regulation (activated) of Smad1
4) Confidence 0.26 Published 2010 Journal Cancer Metastasis Rev Section Body Doc Link PMC2933845 Disease Relevance 0.41 Pain Relevance 0
Endoglin’s suppression of prostate cancer cell invasion is mediated by the activation of the transcription factor Smad1 [158] (see Fig. 4).
Positive_regulation (activation) of Smad1 associated with reprotox - general 1
5) Confidence 0.24 Published 2010 Journal Cancer Metastasis Rev Section Body Doc Link PMC2933845 Disease Relevance 0.49 Pain Relevance 0

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox