INT32979

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.50
First Reported 1985
Last Reported 2010
Negated 1
Speculated 1
Reported most in Body
Documents 5
Total Number 6
Disease Relevance 0
Pain Relevance 5.54

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Golgi apparatus (OPRM1) endoplasmic reticulum (OPRM1) plasma membrane (OPRM1)
signal transducer activity (OPRM1)
Anatomy Link Frequency
plasma 2
OPRM1 (Homo sapiens)
Pain Link Frequency Relevance Heat
opioid receptor 272 100.00 Very High Very High Very High
mu opioid receptor 94 100.00 Very High Very High Very High
Enkephalin 19 100.00 Very High Very High Very High
opiate 8 100.00 Very High Very High Very High
Immobilon 4 99.68 Very High Very High Very High
Morphine 54 98.96 Very High Very High Very High
antagonist 90 97.90 Very High Very High Very High
narcan 108 92.32 High High
Kinase C 6 92.32 High High
Opioid 74 75.80 Quite High
Disease Link Frequency Relevance Heat
Vibrio Infection 1 45.44 Quite Low
Irritable Bowel Syndrome /

Irritable Bowel Syndrome Super

64 40.44 Quite Low
Irritable Bowel Syndrome /

Irritable Bowel Syndrome Super / Visceral Pain

30 5.00 Very Low Very Low Very Low
Pain 23 5.00 Very Low Very Low Very Low
Nociception 14 5.00 Very Low Very Low Very Low
Skin Cancer 3 5.00 Very Low Very Low Very Low
Toxicity 2 5.00 Very Low Very Low Very Low
Disease 2 5.00 Very Low Very Low Very Low
Colitis 2 5.00 Very Low Very Low Very Low
Hyperalgesia 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
DAMGO induced arrestin-2 translocation to the plasma membrane and considerable MOR1 internalization, whereas morphine did not induce arrestin-2 translocation and induced very little MOR1 internalization.
Positive_regulation (induced) of Localization (translocation) of MOR1 in plasma associated with morphine
1) Confidence 0.50 Published 2006 Journal Mol. Pharmacol. Section Abstract Doc Link 16682505 Disease Relevance 0 Pain Relevance 1.70
Similarly, exposure of the sst(2A)-MOR1 heterodimer to the mu-selective ligand [d-Ala(2),Me-Phe(4),Gly(5)-ol]enkephalin induced phosphorylation and desensitization of both MOR1 and sst(2A) but not internalization of sst(2A).
Positive_regulation (induced) of Localization (internalization) of MOR1 associated with enkephalin
2) Confidence 0.50 Published 2002 Journal J. Biol. Chem. Section Abstract Doc Link 11896051 Disease Relevance 0 Pain Relevance 0.30
Chronic ethanol induces changes in opiate receptor function and in met-enkephalin release.
Positive_regulation (induces) of Localization (release) of opiate receptor associated with enkephalin, opiate and immobilon
3) Confidence 0.48 Published 1985 Journal Alcohol Section Title Doc Link 2990502 Disease Relevance 0 Pain Relevance 0.97
To investigate whether exposure of SKNMCs to H2S induces MOR internalization, cells were treated with the ?
Spec (whether) Positive_regulation (induces) of Localization (internalization) of MOR associated with opioid receptor
4) Confidence 0.08 Published 2010 Journal Mol Pain Section Body Doc Link PMC2908066 Disease Relevance 0 Pain Relevance 0.56
MOR may subsequently release from both its native G protein and from FLNA itself leading to association with Gs without FLNA in the complex.
Positive_regulation (subsequently) of Neg (without) Localization (release) of MOR associated with mu opioid receptor
5) Confidence 0.08 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2212716 Disease Relevance 0 Pain Relevance 1.42
Similarly, CTAP was effective in preventing MOR internalization induced by DAMGO but only partially prevented cytosolic MOR translocation induced by Na2S treatment (Figure 6, panel B).


Positive_regulation (induced) of Localization (translocation) of MOR associated with antagonist and opioid receptor
6) Confidence 0.07 Published 2010 Journal Mol Pain Section Body Doc Link PMC2908066 Disease Relevance 0 Pain Relevance 0.59

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox