INT329796

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Context Info
Confidence 0.02
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 0.89
Pain Relevance 0.15

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (TICAM1) signal transduction (TICAM1) plasma membrane (TICAM1)
signal transducer activity (TICAM1)
TICAM1 (Homo sapiens)
IFNA1 (Homo sapiens)
Pain Link Frequency Relevance Heat
cytokine 44 74.68 Quite High
Inflammation 44 66.72 Quite High
adenocard 2 52.80 Quite High
chemokine 8 43.32 Quite Low
psoriasis 19 5.00 Very Low Very Low Very Low
agonist 8 5.00 Very Low Very Low Very Low
fibrosis 7 5.00 Very Low Very Low Very Low
antagonist 3 5.00 Very Low Very Low Very Low
corticosteroid 2 5.00 Very Low Very Low Very Low
cINOD 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Hepatitis C Virus Infection 72 93.48 High High
INFLAMMATION 47 66.72 Quite High
Cancer 25 64.48 Quite High
Necrosis 2 64.00 Quite High
Hepatocellular Cancer 76 50.00 Quite Low
Infection 24 22.72 Low Low
Skin Cancer 29 5.00 Very Low Very Low Very Low
Cirrhosis 28 5.00 Very Low Very Low Very Low
Dermatitis 28 5.00 Very Low Very Low Very Low
Psoriasis 27 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
While most TLRs signal through the Myd88 pathway (Myeloid differentiation factor-88), TLR 3 and 4 utilize the TRIF pathway (TIR domain-containing adapter protein that induces IFN-?)
TIR domain-containing adapter protein Positive_regulation (induces) of IFN
1) Confidence 0.02 Published 2010 Journal Mediators of Inflammation Section Body Doc Link PMC2933899 Disease Relevance 0.25 Pain Relevance 0.08
NS3-4a has also been demonstrated to inactivate the cellular protein toll-interleukin-1 receptor domain-containing adaptor inducing IFN (TRIF).
toll-interleukin-1 receptor domain-containing adaptor Positive_regulation (inducing) of IFN
2) Confidence 0.02 Published 2010 Journal J Transl Med Section Body Doc Link PMC2991329 Disease Relevance 0.64 Pain Relevance 0.06

General Comments

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