INT329798

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Context Info
Confidence 0.01
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 0.24
Pain Relevance 0.10

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (MYD88, TICAM1) signal transduction (MYD88, TICAM1) plasma membrane (MYD88, TICAM1)
intracellular (MYD88) signal transducer activity (TICAM1) cytoplasm (MYD88)
MYD88 (Homo sapiens)
TICAM1 (Homo sapiens)
Pain Link Frequency Relevance Heat
cytokine 28 78.80 Quite High
Inflammation 36 65.36 Quite High
chemokine 6 33.12 Quite Low
psoriasis 19 5.00 Very Low Very Low Very Low
agonist 7 5.00 Very Low Very Low Very Low
Bile 6 5.00 Very Low Very Low Very Low
tolerance 4 5.00 Very Low Very Low Very Low
antagonist 3 5.00 Very Low Very Low Very Low
Glutamate 3 5.00 Very Low Very Low Very Low
corticosteroid 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
INFLAMMATION 33 65.36 Quite High
Cancer 8 63.12 Quite High
Necrosis 1 62.64 Quite High
Infection 44 29.68 Quite Low
Skin Cancer 29 5.00 Very Low Very Low Very Low
Dermatitis 28 5.00 Very Low Very Low Very Low
Psoriasis 27 5.00 Very Low Very Low Very Low
Disease 20 5.00 Very Low Very Low Very Low
Fever 11 5.00 Very Low Very Low Very Low
Acne 11 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
While most TLRs signal through the Myd88 pathway (Myeloid differentiation factor-88), TLR 3 and 4 utilize the TRIF pathway (TIR domain-containing adapter protein that induces IFN-?)
Myeloid differentiation factor-88 Binding (utilize) of TIR domain-containing adapter protein
1) Confidence 0.01 Published 2010 Journal Mediators of Inflammation Section Body Doc Link PMC2933899 Disease Relevance 0.24 Pain Relevance 0.06
MyD88 appears to be the key adaptor molecule, because it is required for signaling by all TLRs with only one exception: TLR3 uses TRIF [7].
MyD88 Binding (uses) of TRIF
2) Confidence 0.01 Published 2010 Journal International Journal of Inflammation Section Body Doc Link PMC3003996 Disease Relevance 0 Pain Relevance 0.04

General Comments

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