INT329803

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Context Info
Confidence 0.01
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 0.94
Pain Relevance 0.41

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (IL6) signal transduction (TLR2) aging (IL6)
extracellular region (IL6) plasma membrane (TLR2) intracellular (TLR2)
Anatomy Link Frequency
Immune cells 2
TLR2 (Homo sapiens)
IL6 (Homo sapiens)
Pain Link Frequency Relevance Heat
cytokine 24 99.28 Very High Very High Very High
Inflammatory response 1 95.92 Very High Very High Very High
chemokine 6 92.12 High High
Inflammation 29 88.52 High High
Neuropeptide 1 80.16 Quite High
cINOD 1 51.80 Quite High
psoriasis 19 46.92 Quite Low
agonist 7 39.04 Quite Low
corticosteroid 2 6.72 Low Low
antagonist 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Acne 11 99.58 Very High Very High Very High
INFLAMMATION 30 95.92 Very High Very High Very High
Adhesions 1 91.12 High High
Psoriasis 27 46.92 Quite Low
Dermatitis 28 11.96 Low Low
Skin Diseases 6 11.04 Low Low
Skin Cancer 29 5.00 Very Low Very Low Very Low
Disease 14 5.00 Very Low Very Low Very Low
Cancer 8 5.00 Very Low Very Low Very Low
Infection 4 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Immune cells such as TLR 2 expressing macrophages (perifollicular and peribulbar) tend to surround pilosebaceous follicles in acne lesions; subsequent TLR 2 triggering due to P. acnes results in IL-6, IL-8, and IL-12 cytokine production [4].
TLR 2 Positive_regulation (triggering) of Positive_regulation (results) of IL-6 in Immune cells associated with acne and cytokine
1) Confidence 0.01 Published 2010 Journal Mediators of Inflammation Section Body Doc Link PMC2933899 Disease Relevance 0.94 Pain Relevance 0.41

General Comments

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