INT32983

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Context Info
Confidence 0.47
First Reported 1983
Last Reported 2008
Negated 0
Speculated 0
Reported most in Abstract
Documents 8
Total Number 8
Disease Relevance 0.42
Pain Relevance 2.60

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Lct) carbohydrate metabolic process (Lct)
Anatomy Link Frequency
plasma 5
serotonin neurons 1
pars distalis 1
Rat2 1
Lct (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Analgesic 2 99.24 Very High Very High Very High
Serotonin 18 98.96 Very High Very High Very High
opiate 2 94.28 High High
dexamethasone 5 90.32 High High
Pain 2 89.92 High High
Morphine 6 82.60 Quite High
anesthesia 12 75.64 Quite High
halothane 4 75.20 Quite High
antagonist 4 69.68 Quite High
agonist 5 68.08 Quite High
Disease Link Frequency Relevance Heat
Pain 2 89.92 High High
Shock 2 89.00 High High
Stress 3 74.76 Quite High
Toxicity 3 5.00 Very Low Very Low Very Low
Acquired Immune Deficiency Syndrome Or Hiv Infection 2 5.00 Very Low Very Low Very Low
Immunization 1 5.00 Very Low Very Low Very Low
Pressure And Volume Under Development 1 5.00 Very Low Very Low Very Low
Cancer 1 5.00 Very Low Very Low Very Low
Cold Sores 1 5.00 Very Low Very Low Very Low
Herpes Simplex Virus 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Together, these findings indicate that serotonergic drugs predominantly influence the release of beta-END-LI resembling beta-LPH and further suggest that serotonin neurons preferentially regulate the release of beta-END-LI from AL corticotrophs in vivo.
Localization (release) of beta-LPH in serotonin neurons associated with serotonin
1) Confidence 0.47 Published 1983 Journal Life Sci. Section Abstract Doc Link 6306375 Disease Relevance 0.07 Pain Relevance 0.31
Since the secretion of beta-LPH in vitro clearly distinguishes beta-END-LI release by the AL as compared to the IL, we interpreted changes in plasma levels of immunoreactivity resembling beta-LPH to reflect beta-END-LI release from the AL.
Localization (secretion) of beta-LPH in plasma
2) Confidence 0.47 Published 1983 Journal Life Sci. Section Abstract Doc Link 6306375 Disease Relevance 0 Pain Relevance 0.16
Since the secretion of beta-LPH in vitro clearly distinguishes beta-END-LI release by the AL as compared to the IL, we interpreted changes in plasma levels of immunoreactivity resembling beta-LPH to reflect beta-END-LI release from the AL.
Localization (release) of beta-LPH in plasma
3) Confidence 0.41 Published 1983 Journal Life Sci. Section Abstract Doc Link 6306375 Disease Relevance 0 Pain Relevance 0.17
Chromatographic analysis of the molecular forms of beta-END-LI released into plasma revealed that both beta-END- and beta-lipotropin (beta-LPH)-sized peptides were secreted under the present experimental conditions.
Localization (secreted) of beta-LPH in plasma
4) Confidence 0.18 Published 1984 Journal Proc. Soc. Exp. Biol. Med. Section Abstract Doc Link 6328533 Disease Relevance 0.09 Pain Relevance 0.71
Since the analgesic form of beta-END (beta- END1 -31) is cosecreted with beta-LPH from the pars distalis, increases in the fraction of plasma beta-END-LI corresponding to beta-END in size were probably due to the release of opiate active beta- END1 -31.
Localization (cosecreted) of beta-LPH in pars distalis associated with analgesic and opiate
5) Confidence 0.18 Published 1984 Journal Proc. Soc. Exp. Biol. Med. Section Abstract Doc Link 6328533 Disease Relevance 0.08 Pain Relevance 0.70
Chromatographic analysis of plasma beta-END-LI revealed that most of the beta-END-LI secreted in response to beta-CCE and CGS-8216 resembles beta-lipotropin (beta-LPH), a marker for beta-END-LI release from the AL, in molecular size.
Localization (release) of beta-LPH in plasma
6) Confidence 0.08 Published 1985 Journal Endocrinology Section Abstract Doc Link 2990851 Disease Relevance 0.09 Pain Relevance 0.26
Chromatographic analysis of plasma beta-END-LI revealed that most of the beta-END-LI secreted in response to beta-CCE and CGS-8216 resembles beta-lipotropin (beta-LPH), a marker for beta-END-LI release from the AL, in molecular size.
Localization (secreted) of beta-LPH in plasma
7) Confidence 0.08 Published 1985 Journal Endocrinology Section Abstract Doc Link 2990851 Disease Relevance 0.09 Pain Relevance 0.30
They observed cytotoxicity of amine terminated G7, G5 and acetamide terminated G5 PAMAM dendrimers by release of cytosolic enzymes luciferase (Luc) and Lactase dehydrogenase (LDH) from KB and Rat2 cells.
Localization (release) of Lactase dehydrogenase in Rat2
8) Confidence 0.03 Published 2008 Journal Indian Journal of Pharmaceutical Sciences Section Body Doc Link PMC2792561 Disease Relevance 0 Pain Relevance 0

General Comments

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