INT329838

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Context Info
Confidence 0.19
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 4
Total Number 5
Disease Relevance 3.81
Pain Relevance 0.20

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Tnfsf13b) extracellular region (Tnfsf13b) plasma membrane (Tnfsf13b)
Anatomy Link Frequency
T-cell 1
Tnfsf13b (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammation 53 93.76 High High
fibrosis 9 77.76 Quite High
cytokine 191 52.56 Quite High
rheumatoid arthritis 34 16.32 Low Low
tolerance 32 5.00 Very Low Very Low Very Low
antagonist 23 5.00 Very Low Very Low Very Low
Arthritis 11 5.00 Very Low Very Low Very Low
abatacept 10 5.00 Very Low Very Low Very Low
chemokine 10 5.00 Very Low Very Low Very Low
Bioavailability 6 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Autoimmune Disease 85 99.92 Very High Very High Very High
Disease 134 99.60 Very High Very High Very High
Renal Disease 137 95.20 Very High Very High Very High
INFLAMMATION 59 93.76 High High
Proteinuria 33 91.40 High High
Systemic Lupus Erythematosus 461 81.28 Quite High
Internal Fibrosis 6 78.24 Quite High
Hypergammaglobulinemia 6 73.36 Quite High
Recurrence 12 64.80 Quite High
Apoptosis 9 55.96 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
An alternative approach to block BlyS is atacicept (known as TACI-Ig).
Negative_regulation (block) of BlyS
1) Confidence 0.19 Published 2010 Journal Biologics : Targets & Therapy Section Body Doc Link PMC2943198 Disease Relevance 0.37 Pain Relevance 0.03
BLyS blockers
Negative_regulation (blockers) of BLyS
2) Confidence 0.16 Published 2010 Journal Biologics : Targets & Therapy Section Body Doc Link PMC2943198 Disease Relevance 0.32 Pain Relevance 0
These results provide a basis for understanding the potential effects of BLyS blockade in human disease
Negative_regulation (blockade) of BLyS associated with disease
3) Confidence 0.14 Published 2010 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC2933908 Disease Relevance 0.96 Pain Relevance 0.09
BLyS blockade has little effect on IgG levels in normal mice, but reverses the production of spontaneously produced IgM and IgG autoantibodies in setting of established autoimmunity.
Negative_regulation (blockade) of BLyS associated with autoimmune disease
4) Confidence 0.14 Published 2010 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC2933908 Disease Relevance 1.10 Pain Relevance 0.03
Blockade of BLyS ameliorates B-cell-dependent disease manifestations even in the MRL.lpr/lpr model, but its effectiveness on autonomous T-cell aspects of the disease is limited.
Negative_regulation (Blockade) of BLyS in T-cell associated with disease
5) Confidence 0.14 Published 2010 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC2933908 Disease Relevance 1.06 Pain Relevance 0.06

General Comments

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