INT3299

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Context Info
Confidence 0.68
First Reported 1977
Last Reported 2011
Negated 3
Speculated 1
Reported most in Body
Documents 126
Total Number 127
Disease Relevance 79.45
Pain Relevance 21.91

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (AGT) small molecule metabolic process (AGT) aging (AGT)
extracellular region (AGT) extracellular matrix organization (AGT) cell-cell signaling (AGT)
Anatomy Link Frequency
plasma 12
blood 7
heart 5
kidney 4
sympathetic nervous system 3
AGT (Homo sapiens)
Pain Link Frequency Relevance Heat
Catecholamine 47 100.00 Very High Very High Very High
Clonidine 31 100.00 Very High Very High Very High
Enkephalin 14 100.00 Very High Very High Very High
ischemia 162 99.98 Very High Very High Very High
narcan 13 99.98 Very High Very High Very High
Serotonin 15 99.90 Very High Very High Very High
cINOD 129 99.84 Very High Very High Very High
headache 53 99.82 Very High Very High Very High
bradykinin 96 99.80 Very High Very High Very High
noradrenaline 29 99.80 Very High Very High Very High
Disease Link Frequency Relevance Heat
Myocardial Infarction 642 100.00 Very High Very High Very High
Heart Rate Under Development 275 100.00 Very High Very High Very High
Coronary Artery Disease 164 99.98 Very High Very High Very High
Renal Artery Obstruction 21 99.98 Very High Very High Very High
Hyperinsulinism 36 99.96 Very High Very High Very High
Obesity 352 99.92 Very High Very High Very High
Shock 34 99.92 Very High Very High Very High
Leukostasis 9 99.92 Very High Very High Very High
Pressure And Volume Under Development 438 99.90 Very High Very High Very High
Sepsis 86 99.84 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In contrast, norepinephrine in ischemic patients increased significantly from 1.7 +/- 0.2 (control) to 2.6 +/- 0.3 (maximal pacing) and to 3.0 +/- 0.4 nmol/liter (1 minute after pacing), whereas angiotensin II levels increased from 6.2 +/- 1.4 (control) to 9.3 +/- 2.1 pmol/liter (1 minute after pacing, p less than 0.05).
Positive_regulation (increased) of angiotensin II
1) Confidence 0.68 Published 1991 Journal Am. J. Cardiol. Section Abstract Doc Link 2063779 Disease Relevance 0.49 Pain Relevance 0.41
In addition, the model of dTGR, with its strongly upregulated renin-angiotensin system might behave different from other models.
Positive_regulation (upregulated) of angiotensin
2) Confidence 0.67 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2993950 Disease Relevance 0.81 Pain Relevance 0.18
An upregulation of angiotensin receptors enhances vascular reactivity, with the consequence of high peripheral resistance.
Positive_regulation (upregulation) of angiotensin
3) Confidence 0.67 Published 1995 Journal Anaesthesist Section Abstract Doc Link 7653790 Disease Relevance 1.22 Pain Relevance 0.08
The renin-angiotensin system (RAS) is activated in sepsis, and recent studies implicate Ang II in the pathogenesis of acute lung injury in animal models [14].
Positive_regulation (activated) of angiotensin in lung associated with adult respiratory distress syndrome and sepsis
4) Confidence 0.67 Published 2010 Journal Crit Care Section Body Doc Link PMC2875539 Disease Relevance 0.95 Pain Relevance 0.07
Activation of angiotensin II receptors in brain potentiates the stimulating effect of endogenous opioid neurons on central sympathetic outflow.
Positive_regulation (Activation) of angiotensin II in brain associated with endogenous opioid
5) Confidence 0.66 Published 1983 Journal Peptides Section Title Doc Link 6306616 Disease Relevance 0 Pain Relevance 0.45
These data are consistent with the hypothesis that activation of angiotensin II receptors in brain potentiates the endorphin-induced stimulation of central sympathetic outflow.
Positive_regulation (activation) of angiotensin II in outflow
6) Confidence 0.66 Published 1983 Journal Peptides Section Abstract Doc Link 6306616 Disease Relevance 0 Pain Relevance 0.49
The renin angiotensin system is activated during anaesthesia and operation, and the degree to which this activation takes place depends on the hydration and circulation of the patient.
Positive_regulation (activated) of angiotensin
7) Confidence 0.66 Published 1992 Journal Ugeskr. Laeg. Section Abstract Doc Link 1311881 Disease Relevance 0.20 Pain Relevance 0.07
This may be due to the very high degree of renin–angiotensin system activation in these patients, requiring a dual blockade to be fully reversed.
Positive_regulation (activation) of angiotensin
8) Confidence 0.64 Published 2009 Journal Vascular Health and Risk Management Section Body Doc Link PMC2788599 Disease Relevance 0.61 Pain Relevance 0.07
Finally, in patients with chronic congestive heart failure, activation of the renin–angiotensin system may contribute to the progressive remodeling and dilatation of cardiac chambers.
Positive_regulation (activation) of angiotensin in heart associated with heart rate under development
9) Confidence 0.64 Published 2009 Journal Vascular Health and Risk Management Section Body Doc Link PMC2788599 Disease Relevance 1.00 Pain Relevance 0.12
Activation of the renin–angiotensin system is a typical feature in chronic heart failure and its inhibition remains an important therapeutic target in these patients.
Positive_regulation (Activation) of angiotensin in heart associated with myocardial infarction
10) Confidence 0.64 Published 2009 Journal Vascular Health and Risk Management Section Body Doc Link PMC2788599 Disease Relevance 0.81 Pain Relevance 0.07
This may be due to direct inhibition of the synthesis of vasodilator prostanoids, or it may be due to indirect potentiation of the action of the sympathetic nervous system or of angiotensin II.
Positive_regulation (potentiation) of angiotensin II in sympathetic nervous system
11) Confidence 0.50 Published 1986 Journal Am. J. Med. Section Abstract Doc Link 3092665 Disease Relevance 0.60 Pain Relevance 0.26
Simultaneous with subarachnoid injection, infusion of angiotensin II (2.5 microg/ml) or ephedrine (5 mg/ml) was initiated at 10 ng x kg(-1) x min(-1) and 50 microg x kg(-1) x min(-1), respectively.
Positive_regulation (infusion) of angiotensin II
12) Confidence 0.49 Published 1998 Journal Anesthesiology Section Body Doc Link 9637639 Disease Relevance 0 Pain Relevance 0
Thus, myocardial ischemia activates circulating catecholamines and angiotensin II, accompanied by systemic vasoconstriction.
Positive_regulation (activates) of angiotensin II associated with coronary artery disease, catecholamine, ischemia and increased venous pressure under development
13) Confidence 0.49 Published 1991 Journal Am. J. Cardiol. Section Abstract Doc Link 2063779 Disease Relevance 0.55 Pain Relevance 0.31
However, because only activation of the alpha(2)-adrenergic receptors appears responsible for somnolence, the imidazoline-receptor agonists moxonidine and rilmenidine, both relatively selective for I-receptors, may have superior clinical utility in antihypertensive therapy, since they are sympatholytic and also suppress the generation of angiotensin II.
Positive_regulation (generation) of angiotensin II in superior associated with agonist
14) Confidence 0.49 Published 1996 Journal J. Cardiovasc. Pharmacol. Section Abstract Doc Link 8872295 Disease Relevance 0.09 Pain Relevance 0.34
Hypertension is common among diabetics and has the same pathogenetic mechanisms as insulin resistance, in which the activated renin–angiotensin system contributes to the increased high blood pressure and hyperglycemia.
Positive_regulation (activated) of angiotensin in blood associated with hyperglycemia, diabetes mellitus, hypertension and insulin resistance
15) Confidence 0.49 Published 2010 Journal Molecular Vision Section Body Doc Link PMC2901187 Disease Relevance 2.04 Pain Relevance 0.10
Finally, there was no significant change in the markers of the renin-angiotensin system in the circulating blood although an increase in aldosterone was observed after rapid pacing only in the control group.
Positive_regulation (increase) of angiotensin in blood
16) Confidence 0.49 Published 2008 Journal Indian Pacing and Electrophysiology Journal Section Body Doc Link PMC2267894 Disease Relevance 0.08 Pain Relevance 0
Atrial natriuretic peptide response to NA and angiotensin II may be mediated by changes in blood pressure levels or increased noradrenergic and angiotensinergic receptor activity in the atria or both.
Positive_regulation (increased) of angiotensin in blood associated with natriuresis, cv unclassified under development and noradrenaline
17) Confidence 0.49 Published 1987 Journal Clin. Exp. Pharmacol. Physiol. Section Abstract Doc Link 2959419 Disease Relevance 0.53 Pain Relevance 0.37
In UUO, there is activation of the renin–angiotensin system with production of reactive oxygen species (ROS) and NFkB, which promote macrophage infiltration [37], renal tubular apoptosis and interstitial fibrosis [38].
Positive_regulation (activation) of angiotensin in macrophage associated with fibrosis, ureteral obstruction and apoptosis
18) Confidence 0.49 Published 2010 Journal PLoS ONE Section Body Doc Link PMC3001459 Disease Relevance 1.38 Pain Relevance 0.30
Angiotensin II is considered the most potent intestinal vasoconstrictor, and the splanchnic hemodynamic response to circulatory shock is mediated predominantly by the renin-angiotensin axis [25].
Positive_regulation (mediated) of angiotensin associated with shock
19) Confidence 0.49 Published 1998 Journal Crit Care Section Body Doc Link PMC29001 Disease Relevance 0.89 Pain Relevance 0.07
AII promotes retinal leukostasis by activating the angiotensin
Positive_regulation (activating) of angiotensin associated with leukostasis
20) Confidence 0.49 Published 2008 Journal PPAR Research Section Body Doc Link PMC2396446 Disease Relevance 0.75 Pain Relevance 0.17

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