INT329961

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Context Info
Confidence 0.35
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 1
Total Number 1
Disease Relevance 1.87
Pain Relevance 0.63

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell proliferation (IL2RA) nucleus (PTPN22) plasma membrane (IL2RA)
cytoplasm (PTPN22)
Anatomy Link Frequency
juvenile 1
IL2RA (Homo sapiens)
PTPN22 (Homo sapiens)
Pain Link Frequency Relevance Heat
rheumatoid arthritis 39 99.84 Very High Very High Very High
Arthritis 76 98.86 Very High Very High Very High
Multiple sclerosis 2 5.00 Very Low Very Low Very Low
Inflammation 2 5.00 Very Low Very Low Very Low
Crohn's disease 2 5.00 Very Low Very Low Very Low
spinal inflammation 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Rheumatoid Arthritis 39 99.84 Very High Very High Very High
Juvenile Chronic Polyarthritis 72 98.86 Very High Very High Very High
Autoimmune Disease 11 97.52 Very High Very High Very High
Disease 14 89.32 High High
Disease Susceptibility 2 78.88 Quite High
Arthritis 5 5.00 Very Low Very Low Very Low
Demyelinating Disease 2 5.00 Very Low Very Low Very Low
Diabetes Mellitus 2 5.00 Very Low Very Low Very Low
Low Back Pain 1 5.00 Very Low Very Low Very Low
Rheumatic Diseases 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In juvenile idiopathic arthritis (JIA), another complex genetic autoimmune disease, the strategy of using information from autoimmune disease GWAS or candidate gene studies to help in the search for novel JIA susceptibility loci has been successful, with confirmed association with two genes, PTPN22 and IL2RA.
IL2RA Binding (association) of PTPN22 in juvenile associated with autoimmune disease, juvenile chronic polyarthritis and arthritis
1) Confidence 0.35 Published 2010 Journal Annals of the Rheumatic Diseases Section Abstract Doc Link PMC2935325 Disease Relevance 1.87 Pain Relevance 0.63

General Comments

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